Eutectic Mixture of Local Anaesthetics (EMLA) is recommended for use off-label as a treatment for premature ejaculation (PE). Other topical anaesthetics are available, some of which have been evaluated against oral treatments. The purpose of this systematic review was to evaluate the evidence from randomised controlled trials (RCTs) for topical anaesthetics in the management of PE. Bibliographi...

Volatile anaesthetics relax airway smooth muscle in vitro. The amount of relaxation might depend on the type and concentration of volatile anaesthetics, the calibre and precontraction level of the bronchi, and also on the species considered. These effects were investigated on isolated human bronchi. Isometric relaxations produced by halothane, isoflurane and desflurane bubbled on human bronchia...

Data on electron structure and octanol-water partition coefficients of certain local anaesthetics are compared with the capacity of reversibly block the action potential of the frog sciatic nerve. Some active parts in the molecules of these substances have been shown to be primarily involved in the action of local anaesthetics.

Halothane is thought to cause hepatitis after multiple exposures in certain susceptible patients. Patients undergoing repeated anaesthetics for insertion of radioactive implants for gynaecological neoplasia appear to be particularly at risk. We are reporting three cases in which hepatitis has followed multiple halothane anaesthetics, and discuss them with reference to our present knowledge of t...

This study investigated some aspects of stress research, including, also, the effects of chemical anaesthesia, in two important species for diversification in aquaculture, blackspot seabream, Pagellus bogaraveo and greater amberjack, Seriola dumerilii. The first part of the research (trial 1 and 2) was designed to determine the efficacy of clove oil as an anaesthetic alternative to MS-222. In t...

Muscarinic acetylcholine signalling plays major roles in regulation of consciousness, cognitive functioning, pain perception and circulatory homeostasis. Halothane has been shown to inhibit m1 muscarinic signalling. However, no comparative data are available for desflurane, sevoflurane or isoflurane, nor have the anaesthetic effects on the m3 subtype (which is also prominent in the brain) been ...