Two forms of the enzyme fructoseI ,6-bisphosphate aldolase (EC 4. I .2.13) are known, designated class I and class 11. The enzymes o f class I function by imine formation between the substrate and a catalytically essential lysine residue in the active site, which acts to stabilize the intermediate carbanion (for review, see [ I , 21). The enzymes of class I1 utilize a divalent metal ion to act ...

The demonstration (l-3) of a distinctive pathway of fructose metabolism in liver via the aldol cleavage of fructose l-phosphate emphasized the possibilty in this tissue of an enriched catalytic system for the facilitation of this reaction since the classical fructose-l ,gdiphosphate aldolase isolated from muscle tissue exhibits relatively little activity toward fructose l-phosphate. The early e...

Enzymes are the core for biological transformations in nature. Their structures and functions have drawn enormous attention from biologists as well chemists since last century. The large demand of bioactive molecules pursuit efficiency greenness synthesis spurred rapid development biomimetic chemistry past several decades. Biomimetic asymmetric catalysis, mimicking enzymes, has been recognized ...