Introduction: Hepatitis B and C are major health problems in many countries, especially developing areas. The frequency of hepatitis B is less than 0.8%, and chronic hepatitis C is less than 0.5% in the general population of Yazd in the center of Iran. Large vehicle drivers have some risk factors for acquiring hepatitis B and C infection. This is important because viral hepatitis complications,...

Background: Blood transfusion improves health and saves lives. Safe blood must be ensured for our populations. Quality assurance is a process that includes set of coordinated activities in order to achieve the quality objective. Compliance with management rules medical biology laboratories requires verification methods prior their use. This study aimed verify on-site performance Enzyme Linked I...

Background & Objectives: Hepatitis B is one of the major health problems in the world. Health care workers (HCWs) are at high risk of acquiring hepatitis B virus. The aim of this study was to evaluate the prevalence of HBV infection and the immune response to HBV vaccine among the HCWs in Babol, northern...

SUMMARY To investigate the relationship between studying in the field of laboratory sciences and some of markers of Hepatitis B virus, the prevalence of Hepatitis Bs Ag, Hepatitis Be Ag and their antibodies, were studied in 423 students of Tehran Universities. Using the enzyme linked immunosorbent assay (ELISA) method, it was found that 1.4 % of laboratory sciences students possessed HBsAg,9% ...

BACKGROUND Hepatitis B with its complications has become one of the universal problems. Injection drug use is one of the most important risk factors in the transmission of hepatitis B. Therefore, we assessed hepatitis B virus prevalence among cases with a history of intravenous drug use (IVDU) as the first announcement-based study in this regard. MATERIALS AND METHODS The announcement-based d...

HBs protein is encoded by the pre-S and S genome, and the detection of HBs antigen (HBsAg) in sera is an initial step for the diagnosis of hepatitis B virus (HBV) infection. The “a” determinant region (amino acid residues 124–147) is the main epitope for inducing a protective immune response. Mutations in the “a” determinant region, known as escape mutants, affect antigenicity and hinder attemp...

A major problem with current cancer vaccines is that the induction of CD8 immune responses is rarely associated with antitumor benefits, mainly owing to multiple immune suppressions in established tumor lesions. In this study, we investigated if and how activation of endogenous CD4 T cells could be achieved to influence the suppressive tumor milieu and antitumor effect. We engineered a lentivec...

To evaluate the immune response to hepatitis B vaccination in stable hemodialysis (HD) patients, a retro-prospective investigation was conducted on 68 HD patients. Participants were vaccinated against hepatitis B virus with an intramuscular hepatitis B vaccination schedule, 40 micrograms at 0, 1, and 6 months. The serum antibody level against hepatitis B surface antigen (HBs) in HD patients was...

Seroepidemiological studies conducted in 369 household contacts of 80 acute cases of hepatitis B in Singapore showed that asymptomatic chronic carriers of hepatitis B surface antigen (HBs Ag) are the main source of acute hepatitis B infection. The HBs Ag prevalence rate in asymptomatic household members was 20% compared with a 6% prevalence for the general population. The majority of the househ...