Available component-oriented platforms address software interoperability only at the signature level, while they do not provide suitable mechanisms for adapting components with mismatching interaction behaviour. This paper presents a methodology for automatically developing adaptors capable of solving behaviour mismatches between heterogeneous components. These adaptors are generated from abstr...

Signal transduction pathways are typically controlled by protein-protein interactions, which are mediated by specific modular domains. One hypothetical use of such interaction domains is to generate new signaling pathways and networks during eukaryotic evolution, through the joining of distinct binding modules in novel combinations. In this manner, new polypeptides may be formed that make innov...

Mechanisms for intracellular retention of proteins are induced during adipocytic differentiation of 3T3-L1 cells. To investigate the potential role of clathrin lattices in these retention processes, we performed a morphological and biochemical analysis of coated vesicle components in 3T3-L1 cells. Optical sectioning and image restoration revealed a marked increase in the staining of clathrin an...

We present a Modified-Nodal-Analysis-derived method for developing Wave Digital Filter (WDF) adaptors corresponding to complicated (non-series/parallel) topologies that may include multiport linear elements (e.g. controlled sources and transformers). A second method resolves noncomputable (non-tree-like) arrangements of series/parallel adaptors. As with the familiar 3-port series and parallel a...

The genetic code is thought to have developed from an early system of RNA-dependent peptide synthesis. To investigate one kind of template-like peptide synthesis that might emerge from an RNA world, we constructed highly reactive aminoacyl phosphate oligonucleotides as adaptors that bound to RNA guide sequences. The reactive aminoacyl groups mimic a chemistry found in modern protein biosynthesi...

Software Adaptation promotes the use of specific computational entities called adaptors that guarantee software components will interact in the right way, not only at the signature level, but also at the behavioral, semantic and service levels. Adaptation techniques have proceeded by computing adaptors for closed systems made up of a fixed set of components. This is not satisfactory when the sy...

The acousticrauditory feature "risetime" has been claimed to underlie both the phonetic affricate-fricative distinction and the nonphonetic plucked-string/bowed-string distinction. We used the perceptual adaptation technique to determine whether the risetime differences of the [d$a]-[ba] distinction would therefore be registered by the same mechanism that mediates risetime differences for the p...

Studies have shown that the basal chordate amphioxus possesses an extraordinarily complex TLR system, including 39 TLRs and at least 40 Toll/IL-1R homologous region (TIR) adaptors. Besides homologs to MyD88 and TIR domain-containing adaptor molecule (TICAM), most amphioxus TIR adaptors exhibit domain architectures that are not observed in other species. To reveal how these novel TIR adaptors fu...