Human leukemias are many diseases. Even if discussion is restricted to human acute leukemias, the topic ordinari ly discussed in the context of animal model systems, these still are many diseases. They are subclassif ied by characteristics of cytological type. In some animal model systems one can modify the host by such maneuvers as aging or by sptenectomy or thymectomy and thereby alter the cy...

Acute myelocytic leukemia (AML) in both children and adults is a more complex and resistant disease than acute lymphocytic leukemia. Progress has been slower and therapy more complicated, but with intensive myelosuppressive induction and further postremission therapy one-third of such patients may now achieve longterm survival and probably be cured.’-5 In the Nordic countries (Denmark, Finland,...

mic enzyme that converts daunorubicm to a principal metabolite, daunorubicino!, in the presence of NADPH. This enzyme, found in mammalian tissues and studied in rat tissue preparations and normal human blood components, is also present in human leukemic myeloblasts. The enzymes from both normal and leukemic leukocytes require NADPH for activity, have similar kinetics and substrate saturation ch...

I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

We report an improved single-step synthesis to generate the membrane-permeant acetoxymethyl esters (AM-esters) of cGMP and three cGMP-analogues. These bioactivatable compounds were found to induce cell death in rat IPC-81 cells, a model system for acute myelocytic leukemia, in micromolar doses, while the corresponding non-modified cGMP-analogues were inactive.

T HE OCCURRENCE of multiple cases of chronic myelocytic leukemia in a family is rare and, to our knowledge, has not been reported in identical twins. An analysis of such data may provide evidence for the existence of genetic factors in human leukemia. This is a report of the development of chronic myelocytic leukemia in identical twins and in one of their brothers. (Figure 1 ). In addition, epi...

The advent of MoAb technology has greatly facilitated the identification of various subsets oflymphoid cells [1, 2]. However, most studies have been concentrated on acute lymphoblastic and myelocytic leukemias [14], and relatively few MoAbs that are directed against surface determinants of chronic lymphocytic cells have been reported [5-7]. The reason may be that CLL cell lines are few in numbe...

I T HAS BEEN ONLY RECENTLY that significant progress has been made in the study of leukocyte kinetics and cell proliferation in acute leukemia. This became possible with the introduction of tritiated thymidine (H3TdR), a labeled precursor specffic for DNA.’ With the technic of radioautography, this labeled compound has been employed in vivo to investigate the leukemic cell cycle and cell prolif...

Bacterial asparaginase (L-Asparaginase amidohydrolase, E.C. 3.5.1.1) is a selective and highly effective chemotherapeutic agent extensively used over the world in first-line treatment of acute lymphoblastic leukemia (ALL), Hodgkin disease, acute myelocytic leukemia, acute melanomonocytic leukemia, chronic lymphocytic leukemia, lymphosarcoma, reticlesarcoma and melanosarcoma (Verma et al., 2007)...

The diagnosis is complicated by overlapping disease and gestation-related symptoms. Here we describe a 37-year-old patient who was diagnosed at 26 weeks gestation with acute myelocytic leukemia which presented with shoulder and neck pains, elevated liver enzymes, thrombocytopenia and non-reassuring fetal heart rate required an emergency cesarean delivery. The maternal side of the placenta and t...