INTRODUCTION Recent studies have demonstrated remote effects of renal ischemia/reperfusion (IR) injury on some organs such as brain, liver, and lungs. Oxidative stress is reported to be the cornerstone in such ischemic conditions. Associated apoptosis is also reported in remote lung, liver and myocardial injury after acute kidney injury. So, we postulated that renal IR may affect the pancreas b...

Background: the supplementation of natural antioxidants such plant flavonoids may counteract the deleterious actions of gamma-irradiation and iron overload. Material and Methods: the protective effect of naringin (NIN) against kidney injury induced by γ-irradiation (IRR) (6.5 Gy) and/or iron dextran (ID) (50 mg/kg. b. w) has been studied in rats given 80 mg/kg b.w of NIN for 14 days before, and...

Implication for health policy/practice/research/medical education: Potential kidney protective effects of metformin, might have synergistic effect with some other antioxidants such as medicinal plants. Hypothesis Please cite this paper as: Rafieian-Kopaei M, Baradaran A. Combination of metformin with other antioxidants may increase its renoprotective efficacy. Hypothesis R ecently, much attenti...

background: acute kidney injury (aki) has been recognized as one of the most complex clinical complications in modern medicine, and ischemia/reperfusion (i/r) injury is well-known as a main reason of aki. in addition, aki leads to important systemic consequences such as acute lung injury. this study was designed to investigate the role of erythropoietin (epo) on kidney function makers and tissu...

Neonatal Acute Kidney Injury (AKI) is characterized by a sudden decline in renal function, or failure of physiologic rise glomerular filtrate rate, leading to the kidneys' inability maintain fluid and electrolyte homeostasis.1,2 Despite significant attention given epidemiology acute kidney injury adult older paediatric populations, there paucity data on neonatal AKI. There has been notable lack...

1. Ortega‐Loubon C, Fernández‐Molina M, Carrascal‐Hinojal Y, Fulquet‐Carreras E. Cardiac surgery‐associated acute kidney injury. Ann Card Anaesth 2016;19:687‐98. 2. Gaffney AM, Sladen RN. Acute kidney injury in cardiac surgery. Curr Opin Anaesthesiol 2015;28:50‐9. 3. Berger MM, Soguel L, Shenkin A, Revelly JP, Pinget C, Baines M, et al. Influence of early antioxidant supplements on clinical evo...

Chicken pox is mostly a benign infection of childhood and caused by Varicella Zoster Virus which generally does not lead to any serious complication in an immunocompetent host. Severe potentially lethal complications like varicella pneumonia, encephalitis acute kidney injury are known entity adults but very rare paediatric age group. We present case Acute Kidney Injury (AKI) the form tubulointe...

We analyzed the effects of acute ischemia-reperfusion (KIR) injury on the status of kidney function and architecture in dipeptidyl peptidase4-difficient (DPP4D) rats and the effect of remote small bowel ischemia-reperfusion (BIR) preconditioning. DPP4-deficient (DPP4D) and normal Fischer344 (F344) rats were divided into 6 groups: (1) sham-F344, (2) sham-DPP4D, (3) KIR-F344 (4) KIR-DPP4D, (5) DP...

OBJECTIVE To determine whether the progression and/or improvement of acute kidney injury in critically ill children is associated with mortality. DESIGN Retrospective. SETTING Multidisciplinary, tertiary care, 24-bed PICU. PATIENTS A TOTAL OF: 8,260 patients who were 1 month to 21 years old with no chronic kidney disease admitted between May 2003 and March 2012. INTERVENTIONS We analyze...