objective assessment of risk predictors for adverse neurodevelopmental outcome at 1 year of age in term and near-term infants. material & methods this case-control study was a representative sample of infants from different health-care centers of north and east of tehran. the association between risk factors and delayed motor development (developmental quotient below 70 indicating a significant...

Traumatic brain injury outcomes can be classified as acute or chronic. Acute outcomes refer to injuries that occur immediately at the time of the injury and subsequent short-term consequences. Chronic outcomes refer to adverse outcomes that are more long-term. In mild traumatic brain injury, recovery from acute outcomes typically occurs very rapidly, i.e., within 2 weeks, with full recovery exp...

This Adverse Outcome Pathway (AOP) describes the linkages between perturbation of normal topoisomerase II enzyme function and infant leukaemia. Infant leukaemia is a rare haematological disease (1 in 106 newborns, accounting for 10% all childhood acute lymphoblastic leukaemias) developmental origin, manifesting soon after birth (< 1 year old). The present AOP how interference stressors with ...

BACKGROUND This study examined the long-term effects of nurse-led, individualized education on self-efficacy, self-care compliance, and health-related quality of life (HRQoL) in middle-aged patients with new-onset acute coronary syndrome. METHODS A quasi-experimental pretest-posttest design was used in the study. A cardiovascular nurse provided individualized education to the intervention gro...

OBJECTIVE To assess the efficacy and safety of low dose adrenaline injected subcutaneously to prevent acute adverse reactions to polyspecific antivenom serum in patients admitted to hospital after snake bite. DESIGN Prospective, double blind, randomised, placebo controlled trial. SETTING District general hospital in Sri Lanka. SUBJECTS 105 patients with signs of envenomation after snake b...

BACKGROUND Misdiagnosis of acute appendicitis is a common and crucial problem in general surgery. Graded compression ultrasonography is one of the new diagnostic technique that is reported to have improve the diagnostic accuracy and clinical outcome. The aim of current study is to assess the role of this diagnostic modality in the management of acute appendicitis. METHODS This is a cohort obs...

BACKGROUND The effect of gene variants and their interactions on response to aspirin and clinical adverse outcomes after an acute ischemic stroke (IS) is not fully understood. The aim of this study was to investigate the association of aspirin-relevant gene variants and their interactions with clinical adverse outcomes in IS patients taking aspirin. METHODS A total of 14 variants from six gen...

BACKGROUND Statin therapy is considered an effective measure for the prevention of ischemic stroke. Several recent studies have indicated that treatment with statins, prior to the onset of acute ischemic stroke, may also substantially reduce the severity of stroke and the degree of patient disability. The purpose of the present review is to systematically evaluate the effectiveness of statin pr...

conclusions intravenous paracetamol appears to provide better analgesia than intravenous morphine in acute limb trauma. further larger studies are required. objectives this study was conducted to compare intravenous paracetamol and intravenous morphine sulfate for acute pain reduction in patients with limb trauma. patients and methods in a randomized double-blinded clinical trial, all patients ...

adverse outcome of pregnancy is a potentially dangerous complication of conception and affects 15-20% of pregnancies. according to recent studies increased level of blood antiphospholipids antibodies, if accompanied by predisposing factors, can be an adverse event in human pregnancy. the aim of the present study was to compare the maternal serum levels of anticardiolipin and antiphosphatidyl se...