نتایج جستجو برای: acinar cells

تعداد نتایج: 1385250  

Journal: :Tissue & cell 2014
S Takahashi H Uekita T Kato F Yuge N Ushijima K Inoue T Domon

In atrophic parotid glands induced by liquid diet, acinar cell apoptosis is increased while proliferative activity is reduced. This study aimed to clarify how liquid diet affects submandibular and sublingual glands, including acinar cell apoptosis and proliferation. Seven-week-old male Wistar rats were fed either a liquid (experimental group) or pellet diet (control group) from 3 to 21 days, re...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 1999
David I Yule Christopher W Baker John A Williams

Stimulus-secretion coupling in the pancreatic acinar cell is initiated by the secretagogues CCK and ACh and results in the secretion by exocytosis of the contents of zymogen granules. A key event in this pathway is the G protein-activated production of second messengers and the subsequent elevation of cytosolic-free Ca2+. The aim of this study was therefore to define the heterotrimeric G protei...

Journal: :Clinical Cancer Investigation Journal 2022

A solid pseudopapillary tumor of the pancreas (SPT) is alternatively called a 'Frantz tumor.' It was first named after its discoverer in year 1959. This has been previously designated as papillary epithelial neoplasm, low-grade and neoplasm pancreas. rare pancreatic neoplasm. typically affects young people female predilection. Its histogenesis rather debatable. Acinar, endocrine, ductal...

2011
Soonhong Park Syng-Ill Lee Dong Min Shin

Regulators of G-protein signaling (RGS) proteins are regulators of Ca(2+) signaling that accelerate the GTPase activity of the G-protein α-subunit. RGS1, RGS2, RGS4, and RGS16 are expressed in the pancreas, and RGS2 regulates G-protein coupled receptor (GPCR)-induced Ca(2+) oscillations. However, the role of RGS4 in Ca(2+) signaling in pancreatic acinar cells is unknown. In this study, we inves...

Journal: :Gastroenterology 2011
David A Hess Sean E Humphrey Jeff Ishibashi Barbara Damsz Ann-Hwee Lee Laurie H Glimcher Stephen F Konieczny

BACKGROUND & AIMS Progression of diseases of the exocrine pancreas, which include pancreatitis and cancer, is associated with increased levels of cell stress. Pancreatic acinar cells are involved in development of these diseases and, because of their high level of protein output, they require an efficient, unfolded protein response (UPR) that mediates recovery from endoplasmic reticulum (ER) st...

2016
Ivana Gaziova Daniel Jackson Paul J. Boor Dwayne Carter Zobeida Cruz-Monserrate Cornelis J. Elferink Aditya D. Joshi Bhupendra Kaphalia Craig D. Logsdon Karen Pereira de Castro Lynn Soong Xinrong Tao Suimin Qiu Lisa A. Elferink

Acinar cells represent the primary target in necroinflammatory diseases of the pancreas, including pancreatitis. The signaling pathways guiding acinar cell repair and regeneration following injury remain poorly understood. The purpose of this study was to determine the importance of Hepatocyte Growth Factor Receptor/MET signaling as an intrinsic repair mechanism for acinar cells following acute...

Journal: :American journal of clinical and experimental immunology 2015
Yaser Panahi Shohreh Fakhari Mehdi Mohammadi Mohammad Reza Rahmani Mohammad Saeid Hakhamaneshi Ali Jalili

Many inflammatory chemokines release from leukocytes and pancreatic acinar cells which play important roles in pathophysiology of acute pancreatitis (AP). Of interests, CXCL2 and CCL2 have been shown elevated in the plasma of patients with AP. We have recently found that Glycyrrhizin (GZ) attenuates AP in mice model. In this study, we aimed to investigate the direct effect of GZ on expression l...

Journal: :Veterinary research 1998
M Sozmen P J Brown J W Eveson

Immunohistochemical staining, with a monoclonal antibody specific for cytokeratins 5, 6, 8, 17 and 19 of dog submandibular, sublingual, parotid, palatine, tongue and zygomatic salivary glands resulted in staining of myoepithelial cells, duct epithelial cells (including intercalated, striated and secretory ducts) and some acinar epithelial cells. Differences in acinar staining between glands ref...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2005
G Perides A Sharma A Gopal X Tao K Dwyer B Ligon M L Steer

Supramaximal stimulation of the rat pancreas with CCK, or its analog caerulein, triggers acute pancreatitis and a number of pancreatitis-associated acinar cell changes including intracellular activation of digestive enzyme zymogens and acinar cell injury. It is generally believed that some of these various acinar cell responses to supramaximal secretagogue stimulation are interrelated and inter...

Journal: :Gastroenterology 2021

Background & AimsMolecular evidence of cellular heterogeneity in the human exocrine pancreas has not been yet established because local concentration and cascade hydrolytic enzymes that can rapidly degrade cells RNA upon pancreatic resection. We sought to better understand composition neonates adults healthy diseased conditions using single-cell sequencing approaches.MethodsWe innovated single-...

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