abcg8

effect of flaxseed on serum lipid profile and expression of npc1l1, abcg5 and abcg8 genes in the intestine of diabetic rat

Journal: :avicenna journal of medical biochemistry 0

abbas mohammadi department of biochemistry, afzalipour school of medicine, kerman university of medical sciences, kerman, iran ; physiology research centre, afzalipour school of medicine, kerman university of medical sciences, kerman, iran fateme mirzaei student research committee, hamadan university of medical sciences, hamadan, iran mohammad nabi moradi student research committee, hamadan university of medical sciences, hamadan, iran mohammad jamshidi student research committee, hamadan university of medical sciences, hamadan, iran reza yari department of biology, islamic azad university, boroūjerd branch, boroūjerd, iran tayebeh ghiasvand department of biochemistry and nutrition, hamadan university of medical sciences, hamadan, iran

objectives the aim of this study was to examine the effect of flaxseed on gene expression of intestinal transporters: niemann-pick c1 like 1 (npc1l1), atp-cassette binding proteins g5 (abcg5) and g8 (abcg8). methods animals were randomly divided into 3 groups 8 rats in each group: group1; normal diet, group2; diabetic rats, and group3; diabetic rats + 4% (w/w) flaxseed. after one-month rats wer...

متن کامل

همبستگی پلی مورفیسم d۱۹h ژن abcg۸ با خطر تشکیل سنگ کیسه صفرا

ژورنال: :فصلنامه علوم پزشکی دانشگاه آزاد اسلامی واحد پزشکی تهران 0

سامان میلانی زاده saman milanizadeh msc of cellular and molecular biology, gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iranکارشناس ارشد زیست شناسی سلولی و مولکولی، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی امیرهوشنگ محمد علیزاده amir houshang mohammad alizadeh gastroenterologist, gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iranفوق تخصص گوارش، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه شهید بهشتی پدرام عظیم زاده pedram azimzadeh msc of cellular and molecular biology, gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iranکارشناس ارشد زیست شناسی سلولی و مولکولی، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی سارا رومانی sara romani msc of virology, gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iranکارشناس ارشد ویروس شناسی، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی محمد روشنی mohammad roshani gastroenterologist, kurdistan university of medical sciences, sanandaj, iranفوق تخصص گوارش و کبد، دانشگاه علوم پزشکی کردستان مهسا خوان یغما mahsa khan yaghma msc of biology, gastroenterology and liver diseases research center, shahid beheshti university of medical sciences, tehran, iranکارشناس ارشد زیست شناسی، مرکز تحقیقات بیماری های گوارش و کبد، دانشگاه علوم پزشکی شهید بهشتی سیدرضا محبی

سابقه و هدف: در افراد مبتلا کلسترول بالا، صفرا بیش از اندازه افزایش یافته و باعث اشباع شدن صفرا و تشکیل سنگ می شود. محصول ژن abcg8 در انتقال کلسترول به خارج از سلول عمل می کند و کلسترول محلول در صفرا را به وجود می آورد و به نظر می رسد تغییرات ژنتیکی در توالی این ناحیه باعث تغییر در عملکرد ژن و تشکیل سنگ کیسه صفرا شود. در این مطالعه، همبستگی پلی مورفیسم d19h ژن abcg8 با خطر تشکیل سنگ کیسه صفرا ب...

متن کامل

Structural Role of ABCG5/ABCG8 in Sterol Transport

Journal: :Biophysical Journal 2017

متن کامل

ATP-Binding Cassette Cholesterol Transporters and Cardiovascular Disease Structure and Function of ABC Transporters

2006

John F. Oram Ashley M. Vaughan

A hallmark of atherosclerotic cardiovascular disease (CVD) is the accumulation of cholesterol in arterial macrophages. Factors that modulate circulating and tissue cholesterol levels have major impacts on initiation, progression, and regression of CVD. Four members of the ATP-binding cassette (ABC) transporter family play important roles in this modulation. ABCA1 and ABCG1 export excess cellula...

متن کامل

Relative roles of ABCG5/ABCG8 in liver and intestine

Journal: :Journal of Lipid Research 2015

متن کامل

Crystal structure of the human sterol transporter ABCG5/ABCG8

Journal: :Nature 2016

متن کامل

ABCG5/ABCG8-independent biliary cholesterol excretion in lactating rats

Journal: :American Journal of Physiology-Gastrointestinal and Liver Physiology 2010

متن کامل

High-dose supplemental selenite to male Syrian hamsters fed hypercholesterolaemic diets alters Ldlr, Abcg8 and Npc1l1 mRNA expression and lowers plasma cholesterol concentrations.

Journal: :The British journal of nutrition 2012

Johanne Poirier Kevin A Cockell Kylie A Scoggan W M Nimal Ratnayake Hélène Rocheleau Heidi Gruber Eleonora Swist Philip Griffin Claude Gagnon Stan Kubow

The aim of the present study was to elucidate possible cholesterol-lowering mechanism(s) of high-dose supplemental Se in the form of selenite, a known hypocholesterolaemic agent. Male Syrian hamsters (four groups, ten per group) were fed semi-purified diets for 4 weeks containing 0.1 % cholesterol and 15 % saturated fat with selenite corresponding to varying levels of Se: (1) Se 0.15 parts per ...

متن کامل

Fatty Acid- and Cholesterol Transporter Protein Expression along the Human Intestinal Tract

2010

Christiaan J. Masson Jogchum Plat Ronald P. Mensink Andrzej Namiot Wojciech Kisielewski Zbigniew Namiot Joachim Füllekrug Robert Ehehalt Jan F. C. Glatz Maurice M. A. L. Pelsers

BACKGROUND Protein distribution profiles along the human intestinal tract of transporters involved in the absorption of cholesterol and long-chain fatty acids (LCFA) have been scarcely evaluated. METHODOLOGY/PRINCIPAL FINDINGS In post-mortem samples from 11 subjects, intestinal transporter distribution profiles were determined via Western Blot. Differences in transporter protein levels were s...

متن کامل

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Journal: :Journal of Lipid Research 2005

متن کامل