نتایج جستجو برای: 6 hydroxy dopamine

تعداد نتایج: 1020826  

Journal: :The Journal of pharmacology and experimental therapeutics 2005
Gregory T Collins Jeffrey M Witkin Amy H Newman Kjell A Svensson Peter Grundt Jianjing Cao James H Woods

A specific role for the dopamine D3 receptor in behavior has yet to be elucidated. We now report that dopamine D2/D3 agonists elicit dose-dependent yawning behavior in rats, resulting in an inverted U-shaped dose-response curve. A series of experiments was directed toward the hypothesis that the induction of yawning is a D3 receptor-mediated effect, whereas the inhibition of the yawning observe...

Journal: :The Journal of pharmacology and experimental therapeutics 2010
David F Cummings Spencer S Ericksen Angela Goetz John A Schetz

Conserved serines of transmembrane segment (TM) five (TM5) are critical for the interactions of endogenous catecholamines with alpha(1)- and alpha(2)-adrenergic, beta(2)-adrenergic, and D1, D2, and D3 dopamine receptors. The unique high-affinity interaction of the D4 dopamine receptor subtype with both norepinephrine and dopamine, and the fact that TM5 serine interactions have never been studie...

Journal: :Acta Crystallographica Section E Structure Reports Online 2013

Journal: :Acta Crystallographica Section E Structure Reports Online 2012

Journal: :Acta Crystallographica Section E Structure Reports Online 2010

Journal: :Acta Crystallographica Section E Structure Reports Online 2011

2014
Hong-Bin Zhao Hui Ma Xiao-Qin Ha Ping Zheng Xiao-Yun Li Ming Zhang Ju-Zi Dong Yin-Shu Yang

Parkinson's disease (PD) is a neurodegenerative disorder characterised by the loss of substantia nigra dopaminergic neurons that leads to a reduction in striatal dopamine (DA) levels. Replacing lost cells by transplanting dopaminergic neurons has potential value to repair the damaged brain. Salidroside (SD), a phenylpropanoid glycoside isolated from plant Rhodiola rosea, is neuroprotective. We ...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2014
Luca Toti R Alberto Travagli

Idiopathic Parkinson's disease (PD) is a late-onset, chronic, and progressive motor dysfunction attributable to loss of nigrostriatal dopamine neurons. Patients with PD experience significant gastrointestinal (GI) issues, including gastroparesis. We aimed to evaluate whether 6-hydroxy-dopamine (6-OHDA)-induced degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) ind...

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