نتایج جستجو برای: 212
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Drug addiction is considered a disorder of neuroplasticity in brain reward and cognition systems resulting from aberrant activation of gene expression programs in response to prolonged drug consumption. Non-coding RNAs (ncRNAs) are key regulators of almost all aspects of cellular physiology. MicroRNAs (miRNAs) are small (∼21-23 nucleotides) ncRNAs transcripts that regulate gene expression at th...
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Synergy of specific microRNAs (miRNAs) with cardiovascular risk factors to estimate atherosclerosis presence in ischemic stroke patients has not been investigated. The present study aimed to identify atherosclerosis-related circulating miRNAs and to evaluate interaction with other cardiovascular markers to improve the estimation of atherosclerosis presence. We performed a miRNA profiling study ...
&&&s: A new instnunent has bee” developed, in order to increase the information about the mechanisms involved, which performs spectral analysis of the fluorescence light. This instlwnentation is though to be capable of doiig in viva (lens and anterior chamber) and in vifro measurements. The experimental system consist basically of: a modified slit lamp, with four different excitation wavelength...
(a) [Problem 2.2 in DFT] For u 1 : For u 2 : For u 3 : Note that u 1 = u 2 2 = ∞ 0 1 · dt = ∞, while u ∞ = 1 and P ow(u) = lim T →∞ 1 2T T 0 1 · dt = 1 2. T −T u 2 (t)dt = T 0 u 2 (t)dt = T 0 |u(t)|dt = k−1 i=0 2 2i for 2 2k−1 ≤ T ≤ 2 2k , k ≥ 1. Hence, u 1 = u 2 = ∞ while u ∞ = 1. Finally: P ow(u) = lim T →∞ 1 2T T −T u 2 (t)dt = lim k→∞ 1 2 2k k−1 i=0 2 2i = 1 4 when T = 2 2k−1 , k ≥ 1 ...
Problem 1 (a) Recall that the null space and the range of a matrix A ∈ C m×n are defined as: N (A) = {x ∈ C n |Ax = 0} R(A) = {y ∈ C m |y = Ax, for some x ∈ C n } Note that N (A) is a subspace of C n since it contains 0 ∈ C n (A0 = 0) and is closed under addition and scalar multiplication: x 1 , x 2 ∈ N (A) ⇒ Ax 1 = 0 and Ax 2 = 0 ⇒ Ax 1 + Ax 2 = 0 ⇒ A(x 1 + x 2) = 0 ⇒ x 1 + x 2 ∈ N (A) x ∈ N (...
The central circadian pacemaker, the suprachiasmatic nucleus (SCN), encodes day length information by mechanisms that are not well understood. Here, we report that genetic ablation of miR-132/212 alters entrainment to different day lengths and non-24 hr day-night cycles, as well as photoperiodic regulation of Period2 expression in the SCN. SCN neurons from miR-132/212-deficient mice have signif...
Pathological growth of cardiomyocytes (hypertrophy) is a major determinant for the development of heart failure, one of the leading medical causes of mortality worldwide. Here we show that the microRNA (miRNA)-212/132 family regulates cardiac hypertrophy and autophagy in cardiomyocytes. Hypertrophic stimuli upregulate cardiomyocyte expression of miR-212 and miR-132, which are both necessary and...
The Pb region is characterised by the existence of collective octupole states. Here we populated such states in Pb + Pb deep-inelastic reactions. γ-ray angular distribution measurements were used to infer the octupole character of several E3 transitions. The octupole character of the 2318 keV 17− → 14 in Pb, 2485 keV 19/2− → 13/2 in Pb, 2419 keV 15/2− → 9/2 in Pb and 2465 keV 17/2 → 11/2− in Tl...
RATIONALE Many processes in endothelial cells including angiogenic responses are regulated by microRNAs. However, there is limited information available about their complex cross-talk in regulating certain endothelial functions. AIM The objective of this study is to identify endothelial functions of the pro-hypertrophic miR-212/132 cluster and its cross-talk with other microRNAs during develo...
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