By the mid-19th century about 200,000 miners were employed in a UK coal mining industry still growing with the advances of the Industrial Revolution. Coal miners were long known to suffer poor health but the link to inhaling dust in the mines had not been made. In 1813 George Pearson was the first to suggest that darkening of lungs seen in normal individuals as they aged was caused by inhaled s...

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Introduction: Breast cancer is the most common in women. The treatment of breast carcinoma has advanced last decade and nowadays there are protocols for all stages disease. Depending on histopathology stage treated with surgery, chemotherapy radiotherapy. Regarding radiation, field irradiation includes chest wall patients mastectomy, or glandular tissue conserving surgical approaches. It often ...

Chinese hamster and mouse sarcoma 180 ascites cells, treated with high levels of actinomycin D, still carry out limited poly(A) synthesis. The residual activity, which consists of poly(A) chain extension in the cytoplasm as well as in the nucleus, is essentially insensitive to cordycepin. Nuclear polyadenylation proceeds linearly and involves the gradual extension of unusually long poly(A) sequ...

The chromosomal constitutions of four amethopterin-resistant sublines of cultured Sarcoma 180 cells were compared with those of two sensitive sublines. No correlation between amethopterin resistance and chromosomes was observed. The chromosomal character of a resistant subline was completely retained in the sensitive subline derived from it after 9 months of continuous cultivation in the absenc...

Negative results are reported for five compounds tested against mouse Sarcoma 180. Twelve mice, 18 gm. Rockland and Carworth Farms mice, were used for each test. The tumors were implanted subcutaneously by trocar in the right axilla. When the implants were seven days old the compounds were in jected intraperitoneallytwice a day for seven days. The compounds were tested at the maximum non-lethal...

The effects of dietary-induced acidosis on the growth and rates of complete regression of Sarcoma 180 in mice have been studied. The experiments here reported have demonstrated that mineral acidification of laboratory food produces a late decrease in tumor growth and significantly increases the rates of complete tumor regression. Blood acid-base studies also demonstrate the effects of these die...