نتایج جستجو برای: 1643
تعداد نتایج: 432 فیلتر نتایج به سال:
METHODS We compared active monitoring, radical prostatectomy, and external-beam radiotherapy for the treatment of clinically localized prostate cancer. Between 1999 and 2009, a total of 82,429 men 50 to 69 years of age received a PSA test; 2664 received a diagnosis of localized prostate cancer, and 1643 agreed to undergo randomization to active monitoring (545 men), surgery (553), or radiothera...
Formal methods for thirty years have promised to be the solution for the safety certification headaches of railway software designers. This chapter looks at the current industrial application of formal methods in the railway domain. After a recall of the dawning of formal methods in this domain, recent trends are presented that focus in particular on formal verification by means of model checki...
Abstract For any $r\in [0,1]$ we give an example of a rigid operator whose spectrum is the annulus $\{\lambda\in \mathbb{C} : r \le |\lambda| 1 \} $ . In particular, when $r=0$ this and non-invertible, {\kern1pt}] 0,1 [ invertible but its inverse not rigid. This answers two questions Costakis, Manoussos Parissis [Recurrent linear operators. Complex Anal. Oper. Theory 8 (2014), 1601–1643].
We investigated delay in diagnosing progressive multifocal leukoencephalopathy (PML). The median time from initial symptom to diagnosis was 74 days (range 1-1643) in 111 PML patients seen at our institution from 1993 to 2015. Another diagnosis was considered before PML in nearly two-thirds, and more than three-quarters of patients suffered from diagnostic delay greater than 1 month, irrespectiv...
Experts’ summary: This publication [1] addresses the long-awaited data on patients diagnosed with prostate cancer in the prostate-specific antigen (PSA) era that were randomized between active monitoring (n = 545), radical prostatectomy (+/– lymph node dissection; n = 553), and radiotherapy (plus 3–6 mo androgen deprivation therapy; n = 545). In total, 1643 out of 2664 patients agreed to be ran...
Potassium ion (K+) channels have been recently found to play a critical role in cancer biology. Despite that pharmacologic manipulation of ion channels is recognized as an important therapeutic approach, very little is known about the effects of targeting of K+ channels in cancer. In this study, we demonstrate that use of the Kv11.1 K+ channel activator NS1643 inhibits tumor growth in an in viv...
W artykule podjęto próbę wskazania autora siedemnastowiecznego paszkwilu wymierzonego przeciwko Tatarom Wielkiego Księstwa Litewskiego, a ściślej – zamieszkałym nad Waką w województwie trockim. Przeanalizowano dedykacje i komentarze czterech edycji (1616, 1617, 1640 1643). Zwrócono uwagę na biogram opata benedyktynów Starych Trokach Tomasza Pawłowskiego (ok. 1556–1653), zarządzającego opactwem ...
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