نتایج جستجو برای: 155

تعداد نتایج: 14701  

2017
Hua Yu Weiling Xu Fangchao Gong Baorong Chi Junyi Chen Ling Zhou

MicroRNA-155 (miR-155) is a well-studied miR and acts as an oncomiR in numerous cancer types. However, the biological functions of miR-155 in colon cancer as well as its target genes have remained to be fully elucidated. In order to investigate the biological functions of miR-155, MTT, colony formation and wound healing assays, cell cycle analysis and detection of apoptosis were performed. The ...

2015
Shashi Bala Timea Csak Fatemeh Momen-Heravi Dora Lippai Karen Kodys Donna Catalano Abhishek Satishchandran Victor Ambros Gyongyi Szabo

Circulating miRNAs can be found in extracellular vesicles (EV) and could be involved in intercellular communication. Here, we report the biodistribution of EV associated miR-155 using miR-155 KO mouse model. Administration of exosomes loaded with synthetic miR-155 mimic into miR-155 KO mice resulted in a rapid accumulation and clearance of miR-155 in the plasma with subsequent distribution in t...

Journal: :Hepatitis monthly 2016
Su-Lin Yu Hong Deng Xin-Hua Li Ya-Xin Huang Dong-Ying Xie Zhi-Liang Gao

BACKGROUND Persistent hepatitis B virus (HBV) infection is sustained by inadequate immune responses, either natural or acquired. Recent studies have suggested that immune responses to viral infection may be affected by microRNA (miR)-155, via its involvement in immune cell differentiation and maturation. However, little is known on the specific interaction between miR-155 and HBV in host antivi...

2016
Yuhua Fan Li Liu Kun Fang Tao Huang Lin Wan Youbin Liu Sen Zhang Dongxia Yan Guangnan Li Yanhui Gao Yanjie Lv Yanjun Chen Yingfeng Tu

BACKGROUND The polyphenol resveratrol (Rev) has been reported to exhibit cardioprotective effects, such as inhibition of TAC (transverse aortic constriction) or isoprenaline (ISO)-induced hypertrophy. MicroRNA-155 (miR-155) was found to be decreased in hypertrophic myocardium, which could be further reduced by pretreatment of Rev. The study was designed to investigate the molecular effects of m...

2015
Xuming Hu Jianqiang Ye Aijian Qin Haitao Zou Hongxia Shao Kun Qian

MicroRNA-155 (miR-155) has been as an important controller of TLR3 signalling. However, the interactions between miR-155 and TLR3 are poorly understood. Here, we focused on the regulation of the relationship between miR-155 and TLR3. Sequence analyses and firefly luciferase reporter assay revealed that miR-155 target were present in the coding sequences (CDS) of TLR3. And the expression of the ...

2014
Yang-Yang Hu Wei-Da Dong Yun-Fei Xu Xu-Dong Yao Bo Peng Min Liu Jun-Hua Zheng

BACKGROUND Both circulating and urinary miRNAs may represent a potential noninvasive molecular biomarker capable of predicting chronic kidney disease, and, in the present study, we will investigate the serum and urinary levels of miR-155 in patients with nephrolithiasis. METHODS Serum and urinary levels of miR-155 are quantified in 60 patients with nephrolithiasis; the result was compared to ...

2013
HIROSHI KONO MASAFUMI NAKAMURA TAKAO OHTSUKA YOSUKE NAGAYOSHI YASUHISA MORI SHUNICHI TAKAHATA SHINICHI AISHIMA MASAO TANAKA

The prognosis of gallbladder cancer (GBC) remains poor despite recent advances in diagnostics and therapeutic strategies. Although the role of microRNAs (miRs) in GBC have not been well documented, miR-155 is known to be associated with inflammation-associated carcinogenesis in various types of cancers. The aim of this study was to investigate the clinical significance of miR-155 expression and...

2016
Xiaolin Lin Yujuan Qin Junshuang Jia Taoyan Lin Xia Lin Li Chen Hui Zeng Yanjiang Han Lihong Wu Shun Huang Meng Wang Shenhao Huang Raoying Xie Liqi Liang Yu Liu Ruiyu Liu Tingting Zhang Jing Li Shengchun Wang Penghui Sun Wenhua Huang Kaitai Yao Kang Xu Tao Du Dong Xiao

miR-155 plays critical roles in numerous physiological and pathological processes, however, its function in the regulation of blood glucose homeostasis and insulin sensitivity and underlying mechanisms remain unknown. Here, we reveal that miR-155 levels are downregulated in serum from type 2 diabetes (T2D) patients, suggesting that miR-155 might be involved in blood glucose control and diabetes...

2016
Hui Wang Yihua Bei Peipei Huang Qiulian Zhou Jing Shi Qi Sun Jiuchang Zhong Xinli Li Xiangqing Kong Junjie Xiao

Sepsis-induced myocardial dysfunction represents a major cause of death in intensive care units. Dysregulated microRNAs (miR)-155 has been implicated in multiple cardiovascular diseases and miR-155 can be induced by lipopolysaccharide (LPS). However, the role of miR-155 in LPS-induced cardiac dysfunction is unclear. Septic cardiac dysfunction in mice was induced by intraperitoneal injection of ...

Journal: :Journal of virology 2009
Mohan T Bolisetty George Dy Wayne Tam Karen L Beemon

The oncogenic microRNA miR-155 is upregulated by several oncogenic viruses. The precursor of miR-155, termed bic, was first observed to cooperate with myc in chicken B-cell lymphomas induced by avian leukosis proviral integrations. We identified another oncogenic retrovirus, reticuloendotheliosis virus strain T (REV-T), that upregulates miR-155 in chicken embryo fibroblasts. We also observed ve...

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