Drama managers reconfigure a game in reaction to a player’s actions. In declarative optimization-based drama management (DODM), a game’s story is abstracted as a sequence of plot points; possible drama manager interventions are abstracted as a set of DM actions. The author defines an function evaluating story quality, and some optimization method (currently reinforcement learning) chooses DM ac...

Interactive story writing is a new medium for creative expression. The story “writer” uses a computer game (such as BioWare’s Neverwinter Nights) to create an interactive story where the “reader” is an active participant. The state of the art is that the story (plot, character behaviors, character interactions, conversations, etc.) is specified by writing scripts. Unfortunately, scripting is to...

Our goal is to enable Non Player Characters (NPC) in computer games to exhibit natural behaviors. The quality of behaviors affects the game experience especially in storybased games, which rely on player-NPC interactions. We used Reinforcement Learning to enable NPC companions to develop preferences for actions. We implemented our RL technique in BioWare Corp.’s Neverwinter Nights. Our experime...

Purpose: To evaluate the pharmacokinetics and tissue disposition of macromolecular camptothecin (CPT) drug conjugate, XMT-1001, and irinotecan (CPT-11) in mice bearing HT-29 xenograft tumors. Experimental Design: The antitumor efficacy of XMT-1001 was evaluated in the mouse HT-29 human colon carcinoma xenograft model. XMT-1001 was administered intravenously to female athymic nude (nu/ nu) mice ...

OBJECTIVE The α7 nicotinic acetylcholine receptors (nAChRs) play a vital role in the pathophysiology of neuropsychiatric diseases such as Alzheimer's disease and depression. However, there is currently no suitable positron emission tomography (PET) or Single-Photon Emission Computed Tomography (SPECT) radioligands for imaging α7 nAChRs in brain. Here our aim is to radiosynthesize a novel SPECT ...

BACKGROUND The alpha7 nicotinic acetylcholine receptors (nAChRs) play an important role in the pathophysiology of neuropsychiatric diseases such as schizophrenia and Alzheimer's disease. However, there are currently no suitable positron emission tomography (PET) radioligands for imaging alpha7 nAChRs in the intact human brain. Here we report the novel PET radioligand [11C]CHIBA-1001 for in vivo...