We investigated mammary gland differentiation and cell proliferation in rats after acute exposure to xenoestrogens. Pubertal female Sprague-Dawley rats (six/group) were treated for 1 week with diethylstilbestrol (DES), genistein, o,p'-DDT, Aroclor 1221, Aroclor 1254, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), or the vehicle, sesame oil. Animals were killed 18 hr after the last treatment. Analy...

The development of the mouse mammary gland occurs postnatally. Hormonal activation of local growth factor pathways stimulates rapid elongation and branching of the rudimentary gland through the fatty stroma. Earlier studies showed that GH is required for mammary gland ductal morphogenesis and that IGF-I mediates this action of GH. In the present study we show that adult IGF-I(m/m) mutant mice e...

A fibroadenoma was diagnosed in the mammary gland of a lamb by immunohistochemical method andmeasurement of oestradiol hormone. The tumor was characterized by an encapsulated firm mass with acreamy-white cut surface. Histologically, it consisted of variably-sized sinus ducts, covered by a single ormultiple layers of proliferated epithelial cells, and embedded in a loose connective tissue. Immun...

Objective- The aim of this study was to determine the normal ultrasonographic and morphologic appearance of mammary gland and teat in Caspian mares during lactation and dry period. Design- Experimental study. Animals- Seven mature Caspian mares Procedures- Using a 6.5-8.5 MHz linear transducer the ultrasonographic appearance of lactating and dry mammary glands was determined in 7 mature Casp...

  Although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue. Sarcomas represent less than 1% of primary breast neoplasms. These tumors are at high risk of recurrence and are known to have poor prognosis. Surgical resection is the primary treatment for these lesions and axillary lymph node dissection is no...

although most breast cancers are adenocarcinomas of the mammary gland, primary breast sarcomas may also arise from mammary gland mesenchymal tissue. sarcomas represent less than 1% of primary breast neoplasms. these tumors are at high risk of recurrence and are known to have poor prognosis. surgical resection is the primary treatment for these lesions and axillary lymph node dissection is not r...

Parameters of collagen biosynthesis were determined in mammary cancer tissue. Peptidylproline hydroxylase (PPH) activity was determined in spontaneous primary mammary cancer tissue and normal mammary gland in fat pad. The enzyme was located in the 105,000 X g supernatant of whole-tissue homogenates. Ascorbate, a-ketoglutarate, and ferrous ion were required for enzyme activity of cancerous and c...

During mammary gland involution, the epithelial mesenchymal transition (EMT) process plays an important role in tissue remodelling and in the termination of milk production. Transforming growth factor β (TGFβ) has been known as a central inducer to EMT and contributor to the mammary gland involution. However, the whole mechanism has accomplished the EMT process in mammary gland is still unclear...

BACKGROUND Cross-talk between the aryl hydrocarbon receptor (AHR) and the estrogen receptor (ER) plays a major role in signaling processes in female reproductive organs. OBJECTIVES We investigated the influence of the AHR ligand 3-methylcholanthrene (3-MC) on ER-mediated signaling in mammary gland tissue of ovariectomized (ovx) rats. METHODS After 14 days of hormonal decline, ovx rats were ...

Parameters of collagen biosynthesis were determined in mammary cancer tissue. Peptidylproline hydroxylase (PPH) activity was determined in spontaneous primary mammary cancer tissue and normal mammary gland in fat pad. The enzyme was located in the 105,000 X g supernatant of whole-tissue homogenates. Ascorbate, a-ketoglutarate, and ferrous ion were required for enzyme activity of cancerous and c...