One day in last October I was hurriedly called to see a European child, who was suffering from fever and had a convulsion an hour previously. Three days after characteristic variolar eruptions appeared on the wrist and forehead. The small-pox gradually extended and became confluent. Two days after a younger brother of the child got fever and afterwards small-pox. On the 9th day of his illness t...

Smallpox virus (variola) poses a significant threat as an agent of bioterrorism. To mitigate this risk, antiviral drugs and an improved vaccine are urgently needed. Satisfactory demonstration of protective efficacy against authentic variola will require development of an animal model in which variola produces a disease course with features consistent with human smallpox. Toward this end, cynomo...