Tyrosinase catalyzes the initial, rate-limiting step of melanin synthesis; oxidative conversion L-tyrosine to L-dopa followed by L-dopaquinone means oxygen molecule. possesses bicopper active center capable utilizing molecular oxygen. Metabolic rhododendrol (RD) tyrosinase causes leukoderma in a certain population consumers. Along with cytotoxic RD metabolites, reactive species (ROS) produced d...

ABSTRACT The related structure–activity relationships of cinnamic acid and its derivates have not been studied in details yet. Herein, antityrosinase antioxidant activities 18 compounds were evaluated. results demonstrated that the substituents on phenyl ring led to enhancement inhibition monophenolase weakening diphenolase. Among these tested compounds, 9 was first discovered as a tyrosinase i...

This study reports depigmenting potency of 1,3-selenazol-4-one derivatives, which would be based upon the finding of direct inhibition to mushroom tyrosinase. 1,3-Selenazol-4-one derivatives exhibited inhibitory effect on dopa oxidase activity of mushroom tyrosinase. In this study, inhibitory effects of six kinds of 1,3-selenazol-4-one derivatives (A, B, C, D, E and F) on mushroom tyrosinase we...

N-(3,5-Dihydroxybenzoyl)-6-hydroxytryptamine (2) was a novel inhibitor of L-3,4-dihydroxyphenylalanine (DOPA) oxidase activity of human HMV-II melanoma tyrosinase. The IC₅₀ values for 2 and three reference compounds, N-(3,5-dihydroxybenzoyl)serotonin, 6-hydroxyindole, and kojic acid, were 9.1, 842, 22, and 310 µM, respectively, indicating that the 6-hydroxyindole moiety was more effective than ...

The present study aimed to examine the potential inhibitory activity of oleoylethanolamide (OEA) on α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis and the molecular mechanism(s) involved in the process in B16 mouse melanoma cells. Our data demonstrated that OEA markedly inhibited melanin synthesis and tyrosinase activity in α-MSH-stimulated B16 cells. In addition, the express...

Diacylglycerol (DAG) increases the melanin content of human melanocytes in vitro and increases the pigmentation of guinea pig skin in vivo, but the mechanism(s) underlying those effects remain unknown. In this study, we characterized the role of diacylglycerol kinase (DGK), which phosphorylates DAG to generate phosphatidic acid, in the regulation of pigmentation. Ten isoforms of DGK have been i...

Moringa oleifera L. leaves are known to have very high protein content and contain isoflavones, inhibiting tyrosinase activity. The study was conducted test the inhibitor activity of leaf extract formulate as a skin brightening cream. Research shows that has good an can be developed results cream formulations showed cosmetology properties (pH, homogeneity, spreadibility).