Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...

the genes glutathione s-transferase m1 (gstm1) and gstt1 code for cytosolic enzymes gstµ and gstθ, respectively, which are involved in phase ii metabolism. in human, both genes may be deleted. in the present study, the genetic polymorphisms of gstm1 and gstt1 were detected by pcr method in 236 healthy individuals from shiraz population, fars province, south of iran. the frequency of gstm1 and g...

objective(s):glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. glutathione s-transferases (gsts) are members of multigenic family, which have important role in cells as an antioxidant. in the present study, we examined the polymorphism of gstt1 and gstm1 deletion genotypes (t0m1, t1m0, and t0m0) in 100 glaucoma patients (41with pr...

AD (Alzheimer's disease) is a neurodegenerative disease and the most common form of dementia. One of the pathological hallmarks of AD is the aggregation of extracellular Aβs (amyloid β-peptides) in senile plaques in the brain. The process could be initiated by seeding provided by an interaction between G(M1) ganglioside and Aβs. Several reports have documented the bifunctional roles of Aβs in N...

Genetic susceptibility to the development of chronic obstructive pulmonary disease (COPD) might depend on variation in the activities of enzymes that detoxify cigarette smoke products, such as microsomal epoxide hydrolase (mEPHX) and glutathione S-transferase (GST). It was investigated whether polymorphisms in these genes had any association with susceptibility to COPD and COPD severity. The ge...