While glucose-stimulated insulin secretion depends on Ca(2+) influx through voltage-gated Ca(2+) channels in the cell membrane of the pancreatic β-cell, there is also ample evidence for an important role of intracellular Ca(2+) stores in insulin secretion, particularly in relation to drug stimuli. We report here that thiopental, a common anesthetic agent, triggers insulin secretion from the int...

The aim of this study was to determine the effect of thiopental sodium with that of midazolam-ketamine on relieving agitation after tonsillectomy in children. In a clinical trial, 50 children aged 5-10 years, candidates for tonsillectomy, were randomly divided into two 25-member groups. In the first group, thiopental sodium 5mg/kg/IV, and in the second group combination of midazolam 0.01 mg/kg/...

We describe a six-compartment kinetic and dynamic physiological model of induction of anaesthesia with thiopental. The model included an accurate account of initial drug distribution by representing the inter-relationships between initial vascular mixing, lung kinetics and cardiac output, and the use of the brain as the target organ for anaesthesia (two-compartment sub-model with slight membran...

Polymorphonuclear eosinophilic leucocytes (PME) participate in wound healing processes, the inflammatory response, bronchial asthma, allergies and defence against invading parasites. We have examined the effects of thiopental, methohexital, propofol, etomidate and ketamine on PME chemotaxis in vitro. PME were isolated from venous blood samples of 10 healthy volunteers using multi-stage Percoll ...

citicoline is a natural substance with neuroprotective and repairing effects. it can also increase the phosphor metabolites in cerebral cortex. regarding the various effects of citicoline on central nervous system, this research aims at studying the effects of citicoline on the thiopental sodium anesthesia. six dogs were anesthetized by intravenous injection of 20 mg ∕ kg of 2.5% thiopental sod...

BACKGROUND Bronchospasm is a potential complication in anyone undergoing general anesthesia. Because volatile anesthetics relax bronchial smooth muscle, the effects of two newer volatile anesthetics, desflurane and sevoflurane, on respiratory resistance were evaluated. The authors hypothesized that desflurane would have greater bronchodilating effects because of its ability to increase sympathe...

STUDY OBJECTIVE To evaluate the effect of propofol infusion for both induction and maintenance of anesthesia on hemodynamics and recovery in elderly patients compared with conventional thiopental-isoflurane anesthesia. DESIGN Randomized, prospective, study. SETTING Teaching hospital. PATIENTS 60 nonpremedicated ASA physical status I, II, and III adult elderly patients scheduled to undergo...

BACKGROUND Possible utility of high-dose i.v. melatonin as an anaesthetic adjuvant has not been studied. This study compared its effects with thiopental and propofol. METHODS Sprague Dawley rats were assigned to receive bolus or cumulative i.v. doses of melatonin, thiopental or propofol. Righting reflex, hindpaw withdrawal to a noxious stimulus, response to tail clamping and haemodynamic effe...