Cannabis has been demonstrated to have bronchodilator, anti-inflammatory, and antitussive activity in the airways, but information on the active cannabinoids, their receptors, and the mechanisms for these effects is limited. We compared the effects of Δ(9)-tetrahydrocannabinol, cannabidiol, cannabigerol, cannabichromene, cannabidiolic acid, and tetrahydrocannabivarin on contractions of the guin...

BACKGROUND AND PURPOSE Marijuana smoking is widespread in many countries, and the use of smoked synthetic cannabinoids is increasing. Smoking a marijuana joint leads to bronchodilation in both healthy subjects and asthmatics. The effects of Δ(9) -tetrahydrocannabinol and synthetic cannabinoids on human bronchus reactivity have not previously been investigated. Here, we sought to assess the effe...

Spaceand time-referenced data published on thc Web by general people can be viewed in a dual way: as independent spatiotemporal events and as trajectories of people in the geographical space. These two views suppose diflCrcnt approaches to the analysis, which can yield diflerent kinds of valuable knowledgc about places and about people. Wc present several analysis methods corresponding to thcsc...

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BACKGROUND Although the preclinical literature suggests that cannabinoids produce antinociception and antihyperalgesic effects, efficacy in the human pain state remains unclear. Using a human experimental pain model, the authors hypothesized that inhaled cannabis would reduce the pain and hyperalgesia induced by intradermal capsaicin. METHODS In a randomized, double-blinded, placebo-controlle...

F. WHO Review History: Dronabinol was included in Schedule I of the 1971 Convention on Psychotropic Substances at the time of its adoption as Delta-9tetrahydrocannabinol together with several other isomers of tetrahydrocannabinol. At its 26 meeting, ECDD recommended that dronabinol, which is the (-)-trans isomer of delta-9-tetrahydrocannabinol, be moved to Schedule II, while keeping the other s...

A sensitive, reliable, and automated solid-phase extraction (SPE) method was developed for the simultaneous extraction, confirmation, and quantitation of Ag-tetrahydrocannabinol (THC) and 11-nor-9-carboxy-A%tetrahydrocannabinol (THCCOOH) from whole blood. The extraction was performed on the Zymark RapidTrace SPF Workstation with a reduced solvent volume SPE copolymer cartridge. Quantitative ana...