This study investigated interactions between dietary fat intake and IL-6 polymorphisms on obesity and serum lipids in black and white South African (SA) women. Normal-weight and obese, black and white women underwent measurements of body composition, serum lipids and dietary fat intake, and were genotyped for the IL-6 -174 G>C, IVS3 +281 G>T and IVS4 +869 A>G polymorphisms. In black women the I...

BACKGROUND The prodrug clopidogrel requires activation by cytochrome P-450 (CYP) enzymes for its antiplatelet effect. The genes encoding enzymes for clopidogrel activation are polymorphic, leading to reduced or increased function, depending on the respective genotype. Reduced-function alleles have been associated with an increase in cardiovascular events. METHODS We tested the association of ...

Possession of the apolipoprotein E (APOE) epsilon4 allele is the most frequently associated genetic susceptibility factor for Alzheimer's disease (AD). Recently, new polymorphisms in the regulatory region of the APOE gene have been described. We analysed the effects of three of these mutations (-491 AT, -427 CT and Th1/E47cs) on disease risk in a large case-control study, and tested their impac...

OBJECTIVE It has been reported that single-nucleotide polymorphism (SNP) in the proximal promoter region of apolipoprotein M (apoM) gene may confer the risk in the development of type 2 diabetes (T2D) and coronary artery disease (CAD) in the Han Chinese. However, in a recent study demonstrated that plasma apoM level did not correlated to the coronary heart disease. In the present studies, we in...

In this study, the relationship between IL-1β [-31 C / T] gene polymorphisms in herniated lumbar disc is offered to be investigated. was amplified by PCR [Polymerase Chain Reaction] method. Polymorphic site cut with restriction enzyme Alu I and genotyping were performed. Fifteen subjects (15%) homozygous for C/C allele at -31 position of gene. Of remaining 85 subjects, 64 (64%) heterozygous C/T...

The norepinephrine transporter critically regulates both neurotransmission and homeostasis of norepinephrine in the nervous system. In this study, we report a previously uncharacterized and common A/T polymorphism at -3081 upstream of the transcription initiation site of the human norepinephrine transporter gene [solute carrier family 6, member 2 (SLC6A2)]. Using both homologous and heterologou...

Background: Dilated cardiomyopathy (DCM) is among the most prevalent causes of heart failure and sudden cardiac death worldwide. Nuclear lamin protein coding genes are believed to have a definitive role in DCM phenotype. The rs505058 thymine (T) cytosine (C) polymorphism lamin-A gene one common mutations reported familial previous studies. Objectives: We aimed demonstrate possible this SNP A C ...

objectives the aim of this study was to investigate the possible associations between co-stimulatory molecule gene polymorphisms and viral infections in kidney transplant patients. results cmv active infection was found in 31 of 172 (18.02%) kidney transplant patients. hcv infection was only found in two of the 172 (1.16%) studied patients. significant associations were found between tt and tc ...