We describe a modification of receptor theory for the estimation of observed affinities (K(obs)) and relative efficacies of orthosteric ligands in functional assays that exhibit constitutive activity. Our theory includes parameters for the fractions of the occupied receptor population in the active (intrinsic efficacy, ε) and inactive (ε(i)) states and analogous parameters for the fractions of ...

Introduction The North Dakota Department of Health (NDDoH) collects outpatient ILI data through North Dakota Influenza-like Illness Network (ND ILINet), providing situational awareness regarding the percent of visits for ILI at sentinel sites across the state. Because of increased clinic staff time devoted to electronic health initiatives and an expanding population, we have found sentinel site...

BACKGROUND The differentiation of hypertrophic cardiomyopathy (HCM) from hypertensive left ventricular hypertrophy (H-LVH) on the basis of morphological information obtained by conventional echocardiography is occasionally problematic. We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging (TDI) is able to discriminate HCM from H-LVH. METHODS AND RESULTS Conventi...

We present static and dynamic techniques to visualize perfusion data and to relate perfusion data to morphologic image data. In particular, we describe the integrated analysis of MRI myocardial perfusion data with CT coronary angiographies depicting the morphology. We refined the Bull’s-Eye Plot, a wide-spread and accepted analysis tool in cardiac diagnosis, to show aggregated information of pe...

The distributions, annual sedimentation and atmospheric deposition flux of heavy metals have been studied in sediments of the South Yellow Sea (SYS), in order to evaluate their levels and pollution status. The higher concentrations of heavy metals were generally found in the central part of the SYS, which may be associated with the organic matters due to their high affinity to the metals. Accor...

The structures and biological activities of the isoforms of endothelin (ET) in a reptile are unknown. ET-3, whose primary structure is identical to human ET-3 except for the substitution Phe4 --> Tyr, and a peptide identical to human ET-1 were isolated from an extract of the lung of the alligator, Alligator mississipiensis. Bolus intravenous injections of alligator ET-3 (10, 30, and 100 pmol/kg...

Flexible manufacturing sys tems ( F M S s ) have received considerable at tent ion and evolve to be one of the fastest growing industrial field in the last decade. In these sys tems , m u c h higher e f i c i e n c y of manufacturing can be achieved (owning to their intr insic f lexibility) provided a good scheduling policy i s adopted. In this paper, w e propose a dynamic scheduler wi th a hie...

We consider environment induced decoherence of quantum superpositions to mixtures in the limit in which that process is much faster than any competing one generated by the Hamiltonian H(sys) of the isolated system. While the golden rule then does not apply we can discard H(sys). By allowing for couplings to different reservoirs, we reveal decoherence as a universal short-time phenomenon indepen...

Self organization for e cient distributed search control has received much attention previously but the work presented in this paper repre sents one of the few attempts at demonstrating its viability and utility in an agent based sys tem involving complex interactions within the agent set We discuss experiments with a het erogeneous multi agent parametric design sys tem called L TEAM where mach...