Introduction Estuarine ecosystems are under high anthropogenic pressure and receive a wide Q7 variety of contaminants, including metals. They can remain trapped in estuarine sediments at concentrations for long periods but eventually they be released to the overlying water become toxic resident benthic biota. As consequence, biomonitoring programs surveying health status estuaries coastal areas...

Objective: To investigate the anti ulcer effect of aqueous extract of Azolla filiculoides (AF) in experimentally induced gastric ulceration in male Wistar rats. Methods: Twenty four rats were divided into four groups of six rats in each group. The group I and III rats were fed with standard diet, whereas, group II and IV rats were pre-treated orally with aqueous extract of Azolla filiculoides (...

Src Homology III (SHB) domains are small (55-?0 amino acids) receptor domains that are found in many signaling proteins and are involved in intracellular signaling events.t2 For example, the SH3 domain in the adaptor protein GRB-2 facilitates the coupling of growth factor receptors to an essential switch in growth-related signaling pathways-the guanine nucleotide binding protein Ras.3 Another e...

Background: Alteration in oxidative and nitrosative stress as well as antioxidant status is known to occur in carcinogenesis and during treatment of cancer with chemotherapeutic drugs. Objective: The objective of this study was to evaluate the serum levels of reduced glutathione (GSH) glutathione-stransferase (GST) and nitric oxide (NO • ) in post-operative stage II breast cancer patients under...

Background: Despite marked improvement in therapy and monitoring of patients with insulindependent (type1) diabetes, diabetic nephropathy remains a serious complication, with subsequent endstage renal disease in about 20% of cases. Objective: To investigate in young patients with type1 diabetes whether urine -Glutathione Stransferase to creatinine ratio (-GST:crea) relates to markers of syste...

The polycyclic aromatic hydrocarbon 6-methyl-1,3,8-trichlorodibenzofuran (MCDF) is related to the industrial byproduct dioxin and is a weak agonist and partial antagonist at the aryl hydrocarbon receptor (AhR). Tamoxifen is used for the treatment and prevention of breast cancer and interferes with the interaction of estrogen with estrogen receptor (ER). The combination of MCDF and tamoxifen low...

In this study, the receptors and signals involved in collagen-induced platelet spreading were examined. It was found that platelet spreading on collagen (presenting a polygon shape with a number of filopodialike projections) was inhibited by the anti–integrin a2 antibody, suggesting the involvement of integrin a2b1 in this process. Studies with a glutathione-Stransferase fusion protein that bin...

Glycine receptors (GlyRs) mediate inhibitory neurotransmission in spinal cord and brain stem. They are clustered at inhibitory postsynapses via a tight interaction of their β subunits (GlyRβ) with the scaffolding protein gephyrin. In an attempt to isolate additional proteins interacting with GlyRβ, we performed pull-down experiments with rat brain extracts using a glutathione Stransferase fusio...

DRH strain rats were established by inbreeding a closed colony of Donryu rats continuously fed the chemical hepatocarcinogen 3*-methyl4-dimethylaminoazobenzene for over 10 years. They are highly resistant to chemical induction of liver cancer and preneoplastic lesions. We studied the genetic basis of DRH resistance to preneoplastic lesions by analyzing 108 (F344 3 DRH)F2 male rats fed 3*-methyl...