BACKGROUND The presence of squamous epithelium in the stomach is only occasionally encountered and is associated with prolonged mucosal injury. Squamous metaplasia in patients with cancer is relatively rare and only four cases have been reported in the stomach, all of which have been associated with squamous cell carcinomas. We present the first case of exuberant squamous metaplasia in a patien...

BACKGROUND Metastases to the stomach from an extra-gastric neoplasm are an unusual event, identified in less than 2% of cancer patients at autopsy. The stomach may be involved by hematogenous spread from a distant primary (most commonly breast, melanoma or lung), or by contiguous spread from an adjacent malignancy, such as the pancreas, esophagus and gallbladder. These latter sites may also inv...

Pancreatic cancer carries a poor prognosis, especially invasive ductal carcinoma of the pancreas. We present here the case of a 76-year-old man who developed synchronous double cancers of the stomach and pancreas. He was referred to our hospital in December, 1997, with a provisional diagnosis of carcinoma of the stomach. Laboratory data on admission showed normal levels except for the serum car...

BACKGROUND Gastrointestinal stromal tumors (GISTs) and adenocarcinoma are distinct neoplasms originating from different cell layers. Approximately 20% of patients with GIST develop other cancers. CASE PRESENTATION We report a case of the coexistence of adenocarcinoma and gastrointestinal stromal tumor (GIST). Gastric endoscopy showed the ulcerated tumor with bleeding along the lesser curvatur...

Approximately 23,000 new gastric cancer cases and 12,000 associated deaths occur annually in the United States. Intestinal metaplasia and gastric epithelial dysplasia are precursor lesions to gastric adenocarcinoma, but are not readily detectable clinically, radiographically, or endoscopically. A noninvasive method of precursor detection would require the ability to distinguish precursor lesion...

A collision tumor of the stomach is a rare event. We report the case of a collision tumor of the stomach consisting of an adenocarcinoma and a gastrointestinal stromal tumor (GIST). This is, to our knowledge, the second report in the literature of such a case. A 71-year-old man with abdominal discomfort underwent an esophagogastroduodenoscopy which revealed a tumor of the oesophagogastric junct...

Hepatoid adenocarcinoma (HAC) is a unique type of extrahepatic that histologically mimics the appearance hepatocellular carcinoma (HCC). stomach has poor prognosis with increased potential for liver metastasis. HCC and HAC share clinicopathological immunohistochemical features. The diagnosis metastatic hepatoid to challenging. It often misdiagnosed as carcinoma. diagnostic dilemma more

Hepatoid adenocarcinoma is a special type of extrahepatic adenocarcinoma that morphologically mimics hepatocellular carcinoma (HCC). Clinical and immunohistochemical features of hepatoid adenocarcinoma are similar to those of HCC, such as elevated serum alpha-fetoprotein (AFP) level, immunoreactivity with AFP, polyclonal carcinoembryonic antigen (CEA), and alpha-1 antitrypsin. Because of these ...

Skin metastasis is a rare manifestation of internal malignancy. Presence of cutaneous metastasis can be seen in 6.4% of all malignancy at some point in time. Cutaneous metastases as a presentation of upper gastrointestinal malignancy is far less common (<1%). Here we present a case of poorly differentiated adenocarcinoma of the stomach that presented with extensive metastases of skin, liver and...

We reported three cases with adenocarcinomas of the lung, prostate and stomach, which metastasized to the temporal bone. Two of them had proven adenocarcinoma of the lung and stomach, respectively at the time of the diagnosis of the temporal bone tumor. But the other patient had no known primary malignancy when the tumor in the petrous apex was demonstrated radiologically. First he underwent bi...