نتایج جستجو برای: socs1 gene

تعداد نتایج: 1141759  

Journal: :Journal of immunology 2004
Nigel J Stevenson Serge Haan Angela E McClurg Michael J McGrattan Marilyn A Armstrong Peter C Heinrich James A Johnston

Suppressors of cytokine signaling (SOCS) are encoded by immediate early genes known to inhibit cytokine responses in a classical feedback loop. SOCS gene expression has been shown to be induced by many cytokines, growth factors, and innate immune stimuli, such as LPS. In this paper, we report that the chemoattractants, IL-8 and fMLP, up-regulate SOCS1 mRNA in human myeloid cells, primary human ...

2016
Lin Liu Lin Tan Zhenxin He

OBJECTIVES The aim of this study was to investigate the methylation status and mRNA expression levels of P15, death-associated protein kinase (DAPK), and suppressor of cytokine signaling-1 (SOCS1) genes in multiple myeloma (MM). MATERIALS AND METHODS The bone marrow samples of 54 MM patients were collected and the methylation status of the P15, DAPK, and SOCS1 gene promoter regions was determ...

Journal: :Cardiovascular research 2012
Antonio Cittadini Maria Gaia Monti Guido Iaccarino Maria Carmina Castiello Alfonso Baldi Eduardo Bossone Salvatore Longobardi Alberto Maria Marra Valentina Petrillo Lavinia Saldamarco Matthew John During Luigi Saccà Gianluigi Condorelli

AIMS The suppressors of cytokine signalling (SOCS) are identified inhibitors of cytokine and growth factor signalling that act via the Janus kinase (JAK) signal transducers and activators of transcription (STAT) pathways. Aberrant JAK/STAT signalling promotes progression from hypertrophy to heart failure. Little information is available concerning the role of SOCS in the transition from hypertr...

2017
Christine I. Alston Richard D. Dix

Human cytomegalovirus (HCMV) is a species-specific β-herpesvirus that infects for life up to 80% of the world's population and causes severe morbidity in at-risk immunocompromised populations. Suppressors of cytokine signaling (SOCS)1 and SOCS3 are host proteins that act as inducible negative feedback regulators of cytokine signaling and have been implicated in several ocular diseases and viral...

2009
Jun Wan Jinben Ma Ju Mei Genfa Shan

BACKGROUND Gene targeted therapy refers to any therapy focused on one of the many biological features of the tumor. Such features are mediated by specific genes that are involved in tumor metastasis, recurrence, poor response to chemotherapy and others. Hypoxia is an important pathognomonic feature of many malignant tumors including SCLC (small cell lung cancer). HIF-1alpha, which is induced by...

Journal: :Investigative ophthalmology & visual science 2011
Cheng-Rong Yu Rashid R Mahdi Hyun-Mee Oh Ahjoku Amadi-Obi Grace Levy-Clarke Jenna Burton Amarachi Eseonu Yongjun Lee Chi-Chao Chan Charles E Egwuagu

PURPOSE Suppressors of cytokine signaling (SOCS) proteins regulate the intensity and duration of cytokine signals and defective expression of SOCS1 and SOCS3 has been reported in a number of human diseases. The purpose of this study was to investigate the role of SOCS1 in intraocular inflammatory diseases (uveitis) and whether SOCS1 expression is defective in patients with ocular inflammatory d...

Journal: :Journal of immunology 2006
Sheela Ramanathan Julien Gagnon Chantal Leblanc Robert Rottapel Subburaj Ilangumaran

SOCS1(-/-) mice accumulate within the thymus and periphery CD8(+) lymphocytes that express memory cell markers and display heightened in vitro responses to common gamma-chain cytokines. To investigate whether dysregulated homeostasis of T lymphocytes and acquisition of memory phenotype by CD8(+) cells in SOCS1(-/-) mice were mediated by IL-7 and/or IL-15 in vivo, we have generated SOCS1(-/-)IL-...

2015
Surajit Pathak Alessia Rosaria Grillo Melania Scarpa Paola Brun Renata D'Incà Laura Nai Antara Banerjee Donatella Cavallo Luisa Barzon Giorgio Palù Giacomo Carlo Sturniolo Andrea Buda Ignazio Castagliuolo

Abnormal levels of microRNA (miR)-155, which regulate inflammation and immune responses, have been demonstrated in the colonic mucosa of patients with inflammatory bowel diseases (IBD), although its role in disease pathophysiology is unknown. We investigated the role of miR-155 in the acquisition and maintenance of an activated phenotype by intestinal myofibroblasts (IMF), a key cell population...

Journal: :Journal of immunology 2011
Justin Mostecki Suzanne L Cassel Walter T Klimecki Debra A Stern Judit Knisz Sachiyo Iwashita Penelope Graves Rachel L Miller Maartje van Peer Marilyn Halonen Fernando D Martinez Donata Vercelli Paul B Rothman

SOCS-1 is a critical regulator of multiple signaling pathways, including those activated by cytokines that regulate Ig H chain class switching to IgE. Analysis of mice with mutations in the SOCS-1 gene demonstrated that IgE levels increase with loss of SOCS-1 alleles. This suggested that overall SOCS-1 acts as an inhibitor of IgE expression in vivo. A genetic association study was performed in ...

Journal: :Brazilian oral research 2017
João Antonio Chaves de Souza Andressa Vilas Boas Nogueira Pedro Paulo Chaves de Souza Guilherme José Pimentel Lopes de Oliveira Marcell Costa de Medeiros Gustavo Pompermaier Garlet Joni Augusto Cirelli Carlos Rossa

This study aimed to characterize the dynamics of suppressor of cytokine signaling (SOCS1) expression in a rat model of lipopolysaccharide-induced periodontitis. Wistar rats in the experimental groups were injected three times/week with LPS from Escherichia coli on the palatal aspect of the first molars, and control animals were injected with vehicle (phosphate-buffered saline). Animals were sac...

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