An early and yet indispensable step in the alphaherpesvirus infection is the engagement of host receptors by the viral envelope glycoprotein D (gD). Of the thus-far identified gD receptors, nectin-1 is likely the most effective in terms of its wide usage by multiple alphaherpesviruses for cell entry. The molecular basis of nectin-1 recognition by the gD protein is therefore an interesting scien...

A simultaneous triple culture for adenovirus, cytomegalovirus, and herpes simplex virus, using three different fluorochromes for virus detection and differentiation in the same shell vial, was developed. In evaluations the triple culture performed comparably to separate cultures, required less specimen volume, and was less expensive to perform.

During 1984 the British Co-operative Clinical Group undertook a survey of genitourinary medicine clinics in the United Kingdom to assess the availability of laboratory diagnostic facilities for Chlamydia trachomatis and herpes simplex virus. Of the 115 clinics assessed, 68% (78) had adequate facilities for culture for C trachomatis and 87% (100) for herpes simplex virus.

There are 2 aspects of the Seroepidemiological studies of herpesvirus type 2 and cervical cancer that impose lim itations upon the interpretation of the data. One aspect is the antibody assay systems; the degree of accuracy with which the present assay systems detect past infections with herpesvirus type 2 is not known (27). The 2nd problem is the difficulty in controlling for the attributes of...

Sixty women patients experiencing a first attack of genital herpes were randomly treated with either oral acyclovir for 42 days or oral acyclovir for five days followed by placebo for 37 days. The median time to the first recurrence in patients receiving acyclovir for 42 days was 66.5 days compared with 24 days in those who received acyclovir for only five days (p less than 0.0001). This signif...

In this study the effect of poly I :C-induced interferon on Herpesvirus hominis (HVH) infection in vitro and in vivo was investigated. The in vitro results revealed a significant effect of interferon on infections of HVH strains of different origin in mouse embryonic cells. The in vivo experiments performed in the HVH-mouse system indicate that the effective induction of interferon in an aminal...

The herpes simplex virus VP16-associated protein HCF is a nuclear host-cell factor that exists as a family of polypeptides encoded by a single gene. The mature HCF polypeptides are amino- and carboxy-terminal fragments of a large approximately 300-kD precursor protein that arise through cleavage at one or more centrally located sites. The sites of cleavage are the HCF repeats, highly conserved ...