Abstract Sonic hedgehog medulloblastoma (SHH-MB) is a malignant, highly heterogeneous brain tumor entity, accounting for 30% of all MBs in the pediatric population and characterized by aberrant activation canonical SHH signaling pathway. Although current therapies targeting Smoothened (Smo) have proven promising treatment approach SHH-MB patients, pre-existing or acquired resistance impedes its...

P2X7 receptor (P2X7R) inhibition is critical for reducing the overactivation of its downstream signaling pathway in autoimmune diseases. Phytochemicals are a source medicinal compounds various diseases and contribute to development effective safe P2X7R-targeted drugs. This review aimed at identifying screening novel safe, effective, economically feasible inhibitors P2X7R from phytochemicals ext...

Background: Hepsin, a type II transmembrane serine protease encoded by HPN gene, is commonly overexpressed in prostate and breast cancer. Hepsin protein stabilized Ras-MAPK pathway signaling, downstream, this regulates the degradation of extracellular matrix components activates growth factor pathways, including hepatocyte transforming (TGF) beta pathway. The significance hepsin-dependent signa...

autism is a severe neurodevelopmental disorder that characterized by abnormal bilateral social interaction, deficiency in verbal and nonverbal communication, restricted interests and repetitive behaviors .autism caused by the inappropriate immune response which released several cytokines. one of the most important and main causes of autism is a defect in, the formation of the neuronal synaptic ...

Autism is a severe neurodevelopmental disorder that characterized by abnormal bilateral social interaction, deficiency in verbal and nonverbal communication, restricted interests and repetitive behaviors .autism caused by the inappropriate immune response which released several cytokines. One of the most important and main causes of autism is a defect in, the formation of the neuronal synaptic ...

Inflammatory processes have been shown to be involved in development and progression of neurodegenerative diseases. Mammalian target of rapamycin (mTOR) involves in various cellular processes including autophagy, apoptosis and energy metabolism. Recently, studies have been shown an association between mTOR pathway and inflammation, supporting the role of the pathway in the pathogenesis of infla...

Objective(s): Oxidative stress has been established as a key cause of alcohol-induced hepatotoxicity. Licochalcone B, an extract of licorice root, has shown antioxidative properties. This study was to investigate the effects and mechanisms of licochalcone B in ethanol-induced hepatic injury in an in vitro study. Materials and Methods: An in vitro model of Ethanol-induced cytotoxicity in BRL cel...