نتایج جستجو برای: serum myostatin

تعداد نتایج: 306461  

Journal: :Journal of sports science & medicine 2006
Darryn S Willoughby Colin D Wilborn

Eccentric contractions produce a significant degree of inflammation and muscle injury that may increase the expression of myostatin. Due to its anti- oxidant and anti-flammatory effects, circulating 17-β estradiol (E2) may attenuate myostatin expression. Eight males and eight females performed 7 sets of 10 reps of eccentric contractions of the knee extensors at 150% 1-RM. Each female performed ...

Journal: :European Journal of Heart Failure 2010

2016
Der-Sheng Han Ming-Yen Hsiao Tyng-Guey Wang Ssu-Yuan Chen Wei-Shiung Yang

BACKGROUND Patients with spinal cord injury (SCI) have a higher prevalence of cardiovascular diseases compared to the healthy population. Aerobic exercise training is one of the recommended treatments. However, literature regarding the effect of aerobic training on patients with SCI is scarce. This study evaluated changes in parameters of exercise physiology and serum myokines immediately after...

Journal: :Scientific Reports 2021

Abstract Myostatin, a member of the transforming growth factor-? superfamily, is an attractive target for muscle disease therapy because its role as negative regulator and strength. Here, we describe novel antibody therapeutic approach that maximizes potential myostatin-targeted therapy. We generated antibody, GYM329, specifically binds latent form myostatin inhibits activation. Additionally, v...

Journal: :Journal of Reproduction and Development 2006

    Background and Objectives: The response of myostatin to resistance training with blood flow restriction is not perfectly clear. Therefore, the purpose of this study comparing the effects of eight weeks resistance training with blood flow restriction and traditional resistance training on myostatin, muscle mass and some related-muscle physiological factors in middle-aged women. Materials ...

2017
Bradley T Elliott Peter Herbert Nicholas Sculthorpe Fergal M Grace Daniel Stratton Lawrence D Hayes

Lifelong exercise is associated with regulation of skeletal mass and function, reductions in frailty, and successful aging. Yet, the influence of exercise on myostatin and myostatin-interacting factors is relatively under examined in older males. Therefore, we investigated whether serum total myostatin, free myostatin, follistatin, and growth and differentiation factor 11 (GDF11) were altered f...

2015
Yun-Sil Lee Adam Lehar Suzanne Sebald Min Liu Kayleigh A. Swaggart C. Conover Talbot Peter Pytel Elisabeth R. Barton Elizabeth M. McNally Se-Jin Lee

Myostatin is a secreted signaling molecule that normally acts to limit muscle growth. As a result, there is extensive effort directed at developing drugs capable of targeting myostatin to treat patients with muscle loss. One potential concern with this therapeutic approach in patients with muscle degenerative diseases like muscular dystrophy is that inducing hypertrophy may increase stress on d...

Journal: :American journal of physiology. Endocrinology and metabolism 2001
T J Marcell S M Harman R J Urban D D Metz B D Rodgers M R Blackman

Growth hormone (GH), insulin-like growth factor I (IGF-I), and testosterone (T) are important mediators of muscle protein synthesis, and thus muscle mass, all of which decline with age. We hypothesized that circulating hormones would be related to the transcriptional levels of their respective receptors and that this expression would be negatively related to expression of the myostatin gene. We...

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