This study investigated the suspension of poly(ε-caprolactone) nanoparticles as an ocular delivery system for flurbiprofen (FB-PεCL-NPs) in order to overcome the associated problems, such as stability, sterility, tolerance, and efficacy, with two different FB-PεCL-NP formulations. The formulations were stabilized with poloxamer 188 (1.66% and 3.5%) and submitted individually for freeze-drying a...

purpose : to assess the results of 1-minute and 5-minute schirmer's test (st) when the eyes are open (sto) and closed (stc) in normal participants. methods : in a comparative, observational case series study, 34 normal volunteers were included in the study. inclusion criteria were normal ophthalmologic findings except for refractive errors, no use of contact lenses, no history of previous ...

The chorioallantoic membrane (CAM) containing tiny blood vessels is an alternative to large animals for studies involving angiogenesis and tissue engineering. However, there is no technique to design the direction of growing blood vessels on the CAM at the microscale level for tissue engineering experiments. Here, a methodology is provided to direct blood vessel formation on the surface of a th...

Ott (1, 2) has shown that desoxypyridoxine (2,4-dimethyl-3-hydroxy5hydroxymethylpyridine) and methoxypyridoxine (2-methyl-3-hydroxy4-methoxymethyl-5-hydroxymethylpyridine), analogues of pyridoxine, act as pyridoxine antagonists in the chick. Because of our interest in the effects of metabolic antagonists on the development of the chick embryo (3), and on the behavior of mouse tumors growing on ...

The application of biomaterials used in regenerative endodontics should be traceable. In this study, we checked some basic effects of rendering a fibrin hydrogel radiopaque using an iodine-based contrast agent (iodixanol) approved for systemic application. Fibrin hydrogels were prepared from a fibrin sealant (Tisseel) using either an isotonic iodixanol solution (Visipaque 320, test) or Tris buf...

One of the most practical routine tests for convergence of a positive series makes use of the ratio test. If this test fails, we can use Rabbe's test. When Rabbe's test fails the next sharper criteria which may sometimes be used is the Bertrand's test. If this test fails, we can use a generalization of Bertrand's test and such tests can be continued innitely. For simplicity, we call ratio test,...

OBJECTIVE The distribution of cardiac output to different organs is well described in the mammalian fetus. Chick embryos are not often used in perinatal cardiovascular research and therefore it is not known whether they can serve as an animal model for this purpose. In this study we documented cardiac output distribution in chick embryos at increasing incubation time. METHODS Fertilized eggs ...

Ophthalmia neonatorum, also called neonatal conjunctivitis, acquired during delivery can occur in the first 28 days of life. Commonly caused by the bacterial pathogen Neisseria gonorrhoeae, infection can lead to corneal scarring, perforation of the eye, and blindness. One approach that can be taken to prevent the disease is the use of an ophthalmic prophylaxis, which kills the bacteria on the s...