نتایج جستجو برای: reovirus

تعداد نتایج: 1929  

Journal: :Cancer research 2010
Chandini M Thirukkumaran Michael J Nodwell Kensuke Hirasawa Zhong-Qiao Shi Roman Diaz Joanne Luider Randal N Johnston Peter A Forsyth Anthony M Magliocco Patrick Lee Sandra Nishikawa Bryan Donnelly Matt Coffey Kiril Trpkov Kevin Fonseca Jason Spurrell Don G Morris

Reovirus is a nonattenuated double-stranded RNA virus that exploits aberrant signaling pathways allowing selective cytotoxicity against multiple cancer histologies. The use of reovirus as a potential treatment modality for prostate cancer has not previously been described, and in this study evidence of in vitro and in vivo activity against prostate cancer was seen both in preclinical models and...

2017
Xing Zhao Weiwei Ouyang Cariad Chester Shiqi Long Nianxue Wang Zhixu He

Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells. The direct cytotoxic effects combined with the capacity to trigger an immune response make OV an appealing combination partner in the burgeoning field of cancer immunotherapy. One of the leading OV therapeutic candid...

2015
Masaya IGASE Chung Chew HWANG Matt COFFEY Masaru OKUDA Shunsuke NOGUCHI Takuya MIZUNO

Oncolytic virotherapy is a new strategy for cancer treatment for humans and dogs. Reovirus has been proven to be a potent oncolytic virus in human medicine. Our laboratory has previously reported that canine mast cell tumor and canine lymphoma were susceptible to reovirus. In this study, canine solid tumor cell lines (mammary gland tumor, osteosarcoma and malignant melanoma) were tested to dete...

Journal: :Journal of virology 1998
B Sherry J Torres M A Blum

Reovirus-induced acute myocarditis in mice serves as a model to investigate non-immune-mediated mechanisms of viral myocarditis. We have used primary cardiac myocyte cultures infected with a large panel of myocarditic and nonmyocarditic reassortant reoviruses to identify determinants of viral myocarditic potential. Here, we report that while both myocarditic and nonmyocarditic reoviruses kill c...

Journal: :Applied and environmental microbiology 1984
S M Lipson G Stotzky

Organic matter in sewage, soil, and aquatic systems may enhance or inhibit the infectivity of viruses associated with particulates (e.g., clay minerals, sediments). The purpose of this investigation was to identify the mechanisms whereby organic matter, in the form of defined proteins, affects the adsorption of reovirus to the clay minerals kaolinite and montmorillonite and its subsequent infec...

Journal: :journal of sciences islamic republic of iran 0

purified reovirus type 3 (strain dearing) was treated with monoclonal anti-?l antibody conjugated to ferritin and examined in the electron microscope. virion associated ferritin molecules corresponding to locations of the ?l protein were observed. electron microsocpy of thin sections of these preparations revealed that ferritin conjugates were localized at the vertices of the viral icosahedron....

2016
Fei Yu Hao Wang Longlong Wang Liqun Lu

Reoviruses are potential anticancer agents due to their ability to induce cell death in tumor cells. Grass carp reovirus (GCRV) is one of the best characterized models on reovirus pathogenesis in vitro. However, there is little known about how SUMOylation affects reovirus pathogenesis. The SUMO conjugating enzyme 9 (Ubc9) determines the targets of SUMOylation. Here, the protein interactions bet...

Journal: :Journal of virology 2012
Maya Shmulevitz Shashi A Gujar Dae-Gyun Ahn Adil Mohamed Patrick W K Lee

Reovirus preferentially replicates in transformed cells and is being explored as a cancer therapy. Immunological and physical barriers to virotherapy inspired a quest for reovirus variants with enhanced oncolytic potency. Using a classical genetics approach, we isolated two reovirus variants (T3v1 and T3v2) with superior replication relative to wild-type reovirus serotype 3 Dearing (T3wt) on va...

Journal: :PLoS Pathogens 2008
Pranav Danthi Caroline M. Coffey John S. L. Parker Ty W. Abel Terence S. Dermody

Apoptosis plays an important role in the pathogenesis of reovirus encephalitis. Reovirus outer-capsid protein mu1, which functions to penetrate host cell membranes during viral entry, is the primary regulator of apoptosis following reovirus infection. Ectopic expression of full-length and truncated forms of mu1 indicates that the mu1 phi domain is sufficient to elicit a cell death response. To ...

2014
Radhashree Maitra Raviraja Seetharam Lydia Tesfa Titto A. Augustine Lidija Klampfer Matthew C. Coffey John M. Mariadason Sanjay Goel

Reovirus is a double stranded RNA virus, with an intrinsic preference for replication in KRAS mutant cells. As 45% of human colorectal cancers (CRC) harbor KRAS mutations, we sought to investigate its efficacy in KRAS mutant CRC cells, and examine its impact in combination with the topoisimerase-1 inhibitor, irinotecan. Reovirus efficacy was examined in the KRAS mutant HCT116, and the isogenic ...

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