We present a patient with Burkitt's lymphoma who suffered a severe haemolytic crisis after treatment with rasburicase. This case report underlines the high incidence of glucose-6-phosphate dehydrogenase deficiency in some ethnic groups and the importance of a detailed patient and family history before starting treatment, even in case of emergency. Glucose-6-phosphate dehydrogenase is an essenti...

Abstract Although prevention is vital in managing tumor lysis syndrome (TLS), no study directly compares various regimens. This compared the effectiveness and safety of urate-lowering agents preventing TLS. Databases were searched for randomized controlled trials involving adults with hematologic or solid malignancies on chemotherapy cytoreductive given allopurinol, febuxostat, rasburicase alon...

Uric acid has been linked with increased risk of chronic disease such as cardiovascular disease and this association has been attributed to a pro-inflammatory effect. Indeed, observational studies have shown that high uric acid is associated with high level of pro-inflammatory cytokines in the blood. However, whether high uric acid directly affects inflammation or rather represents a parallel d...

Leonard Johnson, Conrad Tou, Elizabeth Harvey, Erin Morris and Mitchell S. Cairo Stanton C. Goldman, John S. Holcenberg, Jerry Z. Finklestein, Raymond Hutchinson, Susan Kreissman, F. December 1998. the American Society of Hematology Conference in Miami Beach, FL, with lymphoma or leukemia at high risk for tumor lysis : Presented in part at A randomized comparison between rasburicase and allopur...

Tumor lysis syndrome (TLS) is a life-threatening complication of cancer chemotherapy in which hyperuricemia is the principal characteristic. High serum uric acid levels can lead to uric acid precipitation in the renal tubules, which results in acute kidney failure. TLS is typically associated with rapidly dividing cell types observed with high-risk leukemia and lymphoma, which are more prone to...

Urate oxidase is an endogenous enzyme found in most mammals but not in humans. Urate oxidase catalyzes the enzymatic oxidation of uric acid into allantoin, a metabolite that is 5–10 times more soluble in urine than uric acid. With complementary DNA technology it is possible to produce large quantities of the pure recombinant protein [1]. Rasburicase (RS), a recombinant form of urate oxidase, ha...

A 79-year-old male with chronic myelomonocytic leukaemia and extensive bilateral renal stone disease was treated with intravenous rasburicase for persistent hyperuricaemia. Subsequent imaging revealed a complete dissolution of stone burden, avoiding the need for complex, invasive stone surgery and further renal replacement therapy.

Abstract From antibodies to enzyme replacement therapies, biologics and protein drugs have become a major part of the medical market revolutionized medicine. Repeated administration many these drugs, however, leads humoral responses potentially drug failure via neutralization, clearance, or immune related infusion reactions. Once pathogenic anti-drug are formed, patients must take broad immunos...