objectives: mentha longifolia l. (lamiaceae) is an annual herb that is used in the iranian traditional medicine for treating stomach and intestinal disorders. the purpose of this study was to determine the protective effect of m. longifolia on experimental diarrhea in a rat model. materials and methods: the antidiarrheal activity of essential oil of m. longifolia (20-80 mg/kg) was investigated ...

The antidiarrheal effects of chloroform, methanol, and aqueous extracts of Bidens odorata Cav. were investigated at doses of 200 mg/kg on castor-oil-induced diarrhea. The chloroform extract of B. odorata (CBO) reduced diarrhea by 72.72%. The effect of CBO was evaluated on mice with diarrhea induced by castor oil, MgSO4, arachidonic acid, or prostaglandin E2. CBO inhibited the contraction induce...

Acute radiation enteritis is a common side effect of radiation of abdominal or pelvic malignancies, which often occurs during or shortly after radiation therapy. Though the mechanisms of diarrhea after pelvic radiotherapy are incompletely understood, it was suggested that inflammation of the intestinal mucosa was an important pathophysiological factor. 5-aminosalicylate (5-ASA) as an antiinflam...

BACKGROUND During weaning, babies and young animal often experience diarrhea from food intolerance and/or decreasing levels of maternal antibodies, and diarrhea tends to be particularly severe during the early-weaned period, which often exhibits an underdeveloped immune system, a disturbed gut environment and results in nutrient malabsorption and dehydration. It was deduced that neuroendocrine ...

in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

Introduction: Radioisotope scanning is the best method for objective assessment of salivary gland function. Thus, it was used in a randomized trial of concomitant pilocarpine for assessment of radiation-induced xerostomia, in addition to subjective evaluation by an approved questionnaire and objective standard xerostomia grading. Methods: Patients randomized in placebo-controlled trial of...

OBJECTIVE We conducted a pilot study to evaluate the effects of pelvic radiotherapy on biologic markers of oxidative stress and plasma endotoxin levels, and to assess the relationship between the changes of such factors and radiotherapy-related complications. METHODS Twelve gynecologic cancer patients who were treated via pelvic radiotherapy with or without concurrent chemotherapy were enroll...

BACKGROUND This phase I/II study in patients with metastatic castration-resistant prostate cancer (mCRPC) explored ipilimumab as monotherapy and in combination with radiotherapy, based on the preclinical evidence of synergistic antitumor activity between anti-CTLA-4 antibody and radiotherapy. PATIENTS AND METHODS In dose escalation, 33 patients (≥6/cohort) received ipilimumab every 3 weeks × ...

introduction: artemisia dracunculus l. belongs to asteraceae family, and is a medicinal plant widely used in traditional medicine as a remedy for gastrointestinal disturbances. this study was undertaken to evaluate the effects of essential oil of a. dracunculus (eoad) on the rat alimentary tract. methods: the eoad was extracted by clevenger apparatus using hydrodistillation. ld50 was calculated...