introduction: using labeled peptides enjoys high importance in nuclear medicine. somatostatin analogs labeled with different radionuclide are vastly investigated for diagnosis or treatment of somatostatin receptor positive tumors. labeling somatostatin analogs with 99mtc as alternative of 111in needs doing different quality control method for determination of labeling yield and complex stabilit...

This report compiled all abstracts presented in the NKS Workshop on Radioanalytical Chemistry at Risø, Roskilde, Denmark in 2-6 Sept. 2013. Total 35 participants registered to the workshop, among them 18 from Sweden, 5 from Denmark, 3 from Finland, and 3 from Norway, there are also 6 participants from Germany, France, Slovenia, Korea, Turkey, and China. The workshop consists two part, 3 days la...

introduction: the mechanism of action and metabolism of clozapine, a complex drug used in psychopharmacology, is not completely understood. the effects of this compound in human body are related to some interactions with serotonin and dopamine neurotransmitter receptors. to further elucidate the mechanism of action and to support ongoing drug metabolism studies, [14c] clozapine with suitable ra...

This work analyzes the reliability of radiochemical purity control method of99mTc-MIBI used in nuclear medicine services and influence greater presence impurities diagnostic quality obtained images.

Continuous-flow microfluidics has shown increased applications in radiochemistry over the last decade, particularly for both pre-clinical and clinical production of fluorine-18 labeled radiotracers. The main advantages of microfluidics are the reduction in reaction times and consumption of reagents that often result in increased radiochemical yields and rapid optimization of reaction parameters...

4-[F]Fluoroiodobenzene ([F]FIB) is a versatile building block in F radiochemistry used in various transition metalmediated C–C and C–N cross-coupling reactions and [F]fluoroarylation reactions. Various synthesis routes have been described for the preparation of [F]FIB. However, to date, no automated synthesis of [F]FIB has been reported to allow access to larger amounts of [F]FIB in high radioc...

The development of a novel electrochemical methodology to generate carbon-11 carbon monoxide ([11C]CO) from cyclotron-produced carbon-11 carbon dioxide ([11C]CO2) using Ni(cyclam) and Zn(cyclen) complexes is described. This methodology allows up to 10% yields of [11C]CO from [11C]CO2. Produced [11C]CO was subsequently converted to [11C]N-benzylbenzamide under mild conditions with a radiochemica...