Leiomyomas are common smooth muscle neoplasms; however, leiomyomas of the seminal vesicles are extremely rare. We report a case of seminal vesicle leiomyoma in a 55-year-old African American male who underwent robot assisted laparoscopic prostatectomy (RALP) for Gleason 8 (4 + 4) adenocarcinoma. An incidental nodule arising from the left seminal vesicle was discovered during surgery, complicati...

Previous studies have shown that ETS-related protein 81 (ER81), a downstream gene of Human epidermal growth factor receptor 2 (HER2), may form a fusion protein with other proteins after chromosome translocation, leading to tumor formation, such as the fusion with the EWS gene and subsequent induction of Ewing’s sarcoma (Jeon et al., 1995; Janknecht, 2005). Some research data from several groups...

Objective- To compare transabdominal (TA) and transrectal (TR) ultrasonography of the prostate gland. Design- Experimental study. Animals- 10 intact male dogs that required euthanasia for reasons other than prostatic disease. Procedures- Prostatic length (L), width (W) and height (H) were measured in T A (L1, W1 and H1) and TR (L2 and H2...

Spontaneous neoplasms in 930 control Wistar rats from five carcinogenicity bioassays conducted between 1990 and 1995 were reviewed and compared with review findings in studies between 1980 and 1990. Mean survival at 104 weeks was 55% for males and 60% for females, similar to that of the previous review. A total of 1599 neoplasms was diagnosed in 361 (78%) male and 415 (89%) female rats; 1293 (8...

OBJECTIVES We have synthesized the principal advances in the field of the study of epigenetics and specifically DNA methylation regarding the diagnosis of urological neoplasms. ACQUISITION OF EVIDENCE Review of the literature (PubMed, MEDLINE and Cochrane) on the study of DNA methylation in urological neoplasms (prostate cancer, bladder cancer, renal cancer and testicular cancer), considering...

Background & Objective: Some prostatic lesions contain small suspicious foci for prostatic carcinoma in which the morphological features are equivocal. Two immunohistochemical markers namely, cytokeratin 34 beta E12 (Ck34βE12) and α-Methylacyl-CoA racemase (AMACR), were evaluated in these lesions for a definitive diagnosis and avoiding misdiagnosis or overdiagnosis of prostatic...

INTRODUCTION A collision tumor is the meeting and eventual intermingling of two malignant neoplasms arising from independent topographical sites. Collision metastasis of carcinomas in the lymph nodes is a rare event. A literature search revealed only three cases of such a collision metastasis of prostatic and urothelial carcinoma, and only one of those cases had used immunohistochemical stains ...

BACKGROUND The identification of human disease-related microRNAs (disease miRNAs) is important for further investigating their involvement in the pathogenesis of diseases. More experimentally validated miRNA-disease associations have been accumulated recently. On the basis of these associations, it is essential to predict disease miRNAs for various human diseases. It is useful in providing reli...

Isoji Sasagawa, MD, Department of Urology, Yamagata University, School of Medicine, 2-2-2 Iidanishi., Yamagata-shi, Yamagata 990-23 (Japan) Dear Sir, Since Matas et al. [1] first described nine cancers among uremic patients, various neoplasms have been reported to occur in patients on hemodialysis [2, 3]. Recently, a possible relationship between cancer and hemodialysis has been emphasized [4]....

Between March 1970 and December 1978 there were 366 patients with prostatic cancer treated by 125I seed implants and pelvic lymph node dissection. All had a minimum of 5 years follow-up. One hundred thirty-three patients had metastatic prostatic cancer in lymph nodes (Stage D1) at the time of lymph node dissection and seed implantation. Ninety-one of the 133 patients were judged to have suffici...