نتایج جستجو برای: prima donna
تعداد نتایج: 4286 فیلتر نتایج به سال:
Acetylcholinesterase (AChE) accumulates on axonal varicosities and is primarily found as tetramers associated with a proline-rich membrane anchor (PRiMA). PRiMA is a small transmembrane protein that efficiently transforms secreted AChE to an enzyme anchored on the outer cell surface. Surprisingly, in the striatum of the PRiMA knock-out mouse, despite a normal level of AChE mRNA, we find only 2-...
BACKGROUND Since ovarian cancer is associated with high frequency of p53 mutation, the availability of p53 reactivation and induction of massive apoptosis (PRIMA-1) offers a possible new therapeutic strategy for overcoming this devastating disease. Although Akt activation is believed to be a determinant in chemoresistance in ovarian cancer, whether Akt plays a role in regulating the effectivene...
Sommario L’osteoporosi premenopausale viene definita come un’osteoporosi a insorgenza prima della fisiologica cessazione funzione gonadica, in assenza di qualsiasi causa identificabile che possa sottendere la riduzione densità minerale ossea. Vi sono infatti numerose malattie, condizioni oppure farmaci grado determinare una ossea non solo nella donna premenopausa ma anche postmenopausa e nel so...
We recently identified PRIMA-1 as a low molecular weight compound that restores tumor suppressor function to mutant p53 proteins and has anti-tumor activity in vivo (1). Here we report the statistical analysis of the effect of PRIMA-1 on a panel of human tumor cell lines using information available in a database at the Developmental Therapeutics Program of the National Cancer Institute (NCI). W...
Auguste Rodin is the most celebrated sculptor of the 19th century. His works, such as The Gates of Hell, The Thinker, and The Burghers of Calais, are famous worldwide. To our knowledge, no art historians have analyzed three-dimensional data of Rodin's work. This paper describes our project to fill this need by digitally archiving the bronze statue, The Burghers of Calais. First, we scanned the ...
The separation of the contributions to the theory and practice of socialism by Karl Marx and Friedrich Engels was not seriously posited during their lifetimes, but only in the following generation. The separation, as opposed to the contributions of their entire working lives, of the respective quality of thinking in either case, was a matter of which Engels was conscious, for he wrote: "Marx wa...
Seaweed is one of the prima donna marine biota which widely used as a natural antioxidant. Various species seaweed are found growing naturally in waters Kabung Island, West Kalimantan. This study aims to determine phytochemical content and antioxidant activity each genus Turbinaria, Hypnea Caulerpa from those collected Island. extraction uses maceration method with methanol remove active compou...
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