TO THE EDITOR: We greatly appreciate the contributions made by Bergeron and Baskurt and Meiselman (1) and we sincerely agree with their remarks. Although sickle cell trait (SCT) carriers are characterized by blood rheological abnormalities (3) and sometimes hemostatic and vascular cell adhesion perturbations, most of the SCT carriers performed exercise without any symptoms. As underlined by Bas...

16p11.2 deletions and duplications are commonly associated with autism spectrum disorder and linked to mirrored phenotypes of physical characteristics and higher penetrance for deletions. A male with a rare 16p11.2 triplication demonstrated a similar phenotypic presentation to deletion carriers with neurocognitive and adaptive skill deficits and above-average physical growth.

Abstract: This paper investigates a decision-making problem consisting of less-than-truckload dynamic pricing (LTLDP) under Physical Internet (PI). PI can be seen as the interconnection of logistics networks via open PI-hubs, which can be considered as spot freight markets where LTL requests of different volume/destination continuously arrive over time for a short-stay. Carriers can bid for the...

BRCA1 mutation carriers face a high lifetime risk of developing breast cancer. Physical activity induces broad transcriptional changes, and multiple studies have documented its beneficial effects across cancers. Because haploinsufficiency predisposes to breast cancer in these women, factors that increase BRCA1 levels may mitigate the effect of the mutation. Whether physical activity modulates B...

BACKGROUND AND AIM Lynch syndrome, caused by germline mutations in mismatch repair genes, is a predisposing factor for colorectal cancer (CRC). This retrospective cohort study investigated the risk factors associated with the development of CRC in patients with MLH1 and MSH2 germline mutations. METHODS In total, 301 MLH1 and MSH2 germline mutation carriers were identified from the Amsterdam c...

Free electrons or holes can mediate the nonradiative recombination of excitons in carbon nanotubes. Kinematic constraints arising from the quasi-one-dimensional nature of excitons and charge carriers lead to a thermal activation barrier for the process. However, a model calculation suggests that the rate of recombination mediated by a free electron is the same order of magnitude as that of two-...

To assess the effects of regular physical activity on muscle functional characteristics of carriers of sickle cell trait (SCT), 39 untrained (U) and trained (T) hemoglobin (Hb)AA (CON) and SCT subjects (U-CON, n = 12; U-SCT, n = 8; T-CON, n = 10; and T-SCT, n = 9) performed a graded exercise and a time to exhaustion (T(ex)) test, and were subjected to a muscle biopsy. Maximal power, total work ...

objective(s): according to the unique properties of magnetic nanoparticles, nickel metal-organic frameworks (mof) was synthesized successfully by ultrasound irradiation. metal-organic frameworks (mofs) are organic–inorganic hybrid extended networks that are constructed via covalent linkages between metal ions/metal clusters and organic ligands called a linker. materials and methods: the nanopar...

Inorganic perovskite nanocrystals (NCs) have demonstrated a number of unique optical and electronic properties for optoelectronic applications. However, the physical these nanostructures, such as dynamics charge carriers on different timescales their effect recombination carriers, are not yet fully understood. This work reports slow (>1 s) reversible quenching NC photoluminescence due to light-...