introduction: regarding chronic nature of epilepsy and its side effects and to access the effective treatment procedures, herbal medicine has received remarkable interest. the aim of this study was to determine the anticonvulsant effects of hydro-alcoholic extract of anethum graveolens seed on pentylenetetrazol (ptz) -induced seizure in male mice. methods: fifty-six albino male mice were divide...

introduction: epilepsy is a neural disorder in which abnormal plastic changes during short and long term periods lead to increased excitability of brain tissue. kindling is an animal model of epileptogenesis which results in changes of synaptic plasticity due to repetitive electrical or chemical sub-convulsive stimulations of the brain. lateral hypothalamus, as the main niche of orexin neurons ...

Aim: The current study investigated the effects of artemisinin on heart and lung tissue against pentylenetetrazol-induced seizures in mice. For this purpose, malondialdehyde (MDA), advanced oxidation protein products (AOPP), Catalase (CAT), glutathione (GSH), peroxidase (GSH-Px) levels were evaluated both homogenates.Material Method: Swiss albino male mice (n=42) used experiment. Animals divide...

In the present study, the effects of caerulein and CCK receptor antagonist< on tolerance to the anti-pentylenetetrazol activity of diazepam has been studied. Different doses of diazepam (20, 30, 35, 40 and 50 mg/kg) were administered intraperitoneally for a period of 6 days in order to induce tolerance to diazepam. 48 h after the last dose of diazepam, a test dose of diazepam was tested for...

A series of benzylamides of N-alkylated, N-acylated or free nine cyclic and one linear amino acids as potential anticonvulsants have been synthesized. The structures of the obtained compounds were designed on the basis of the previously determined structure and physicochemical properties/anticvonvulsant activity relationship of the formerly synthesized compounds of this type. The obtained compo...

s connected to the Ph.D. thesis Abstracts directly related to the thesis I. Robotka, H., Marosi, M., Németh, H., Toldi, J. and Vécsei, L. Effect of kynurenine (IP) on pentylenetetrazol-induced seizure in the rat hippocampus. IBRO International Workshop, Budapest, 29-31. January, 2004, Clinical Neuroscience 57: 57 II. Robotka, H., Marosi, M., Németh, H., Lür, G., Somlai, C., Toldi, J. and Vécsei...