BACKGROUND Congenital syphilis continues to be a preventable cause of global stillbirth and neonatal morbidity and mortality. Shortages of injectable penicillin, the only recommended treatment for pregnant women and infants with syphilis, have been reported by high-morbidity countries. We sought to estimate current and projected annual needs for benzathine penicillin in antenatal care settings ...

Synthesis of model peptide substrates and investigation of the reaction of their phenylacetyl protecting group enzyme transformation by means of penicillin G acylase D. L. Danalev*, L. K. Yotova 1 Department of Organic Chemistry, University of Chemical Technology and Metallurgy, 8 Kliment Ohridski Blvd., 1756 Sofia, Bulgaria 2 Department of Biotechnology, University of Chemical Technology and M...

The effectiveness of cephalexin, an oral cephalosporin using a dosage equivalent to available capsular dosage forms, was studied in relation to the effectiveness of phenoxymethyl penicillin and benzathine penicillin in the treatment of 128 patients with beta-hemolytic streptococcal pharyngitis, all but six of whom had group A streptococci isolated from throat cultures. Approximately one-half, 6...

Diisopropylamino-cis-2,6-dimethylpiperidinocarbene reacts regio- and diastereoselectively with CO to afford a bicyclic β-lactam with 100% atom efficiency, whose spectrum of activity resembles that of penicillin G or amoxicillin.

It has been shown (Odegaard, 1962) by sensitivity testing in vitro that the effect of ampicillin on most gonococcal strains is somewhat weaker than that of penicillin G, but the effect on strains less sensitive is better with ampicillin than with penicillin G. Reyn and Bentzon (1968), in support of this, found that the 50 per cent. inhibitory concentrations for the naturally-occurring more sens...

Eagle (1947a) has shown that p-hydroxybenzyl penicillin (X) was more effective than benzyl penicillin (G) in curing mice infected with Streptococcus pyogenes and Streptococcus pneumoniae. Hewitt and Pittman (1946) have obtained similar results in animals infected with Hemophilus influenzae. It was further shown that penicillin X remains in the blood of human subjects longer than penicillins G o...

Benzylpenicillin potassium (penicillin G) is a narrow-spectrum penicillin (active against Grampositive aerobes, facultative aerobes and obligate anaerobes), often used in rabbits for treatment of pasteurellosis, odontogenic abscesses and treponematosis. However, several dosages and treatment regimes have been advocated; three times daily, once a day, or once every two or seven days (Welch et al...