There is considerable interest in exploiting metallosupramolecular cages as drug delivery vectors. Recently, we developed a [Pd2L4](4+) cage capable of binding two molecules of cisplatin. Unfortunately, this first generation cage was rapidly decomposed by common biologically relevant nucleophiles. In an effort to improve the kinetic stability of these cage architectures here we report the synth...

The structural and dynamical properties of Pd2+ in liquid ammonia have been investigated via quantum mechanical charge field molecular dynamics. Similar to the case of aqueous Pd2+, a six-fold coordination polyhedron in the form of a tetrahedrally elongated octahedron is observed with two ligands in axial positions forming an extended first shell. To highlight the difference in solvation betwee...

The indexes for agonistic activity (pD2 values) and for antagonistic activity (pA2 values) of some beta-adrenergic partial agonists were estimated in the isolated taenia caecum and tracheal preparation of guinea pig. The pK1 values, negative log of dissociation constants, were also estimated by photoinactivation of the beta-adreneoceptor in the taenia caecum. The pD2 values of the partial agoni...

We investigated the effects of RNAi-mediated gene silencing of vascular endothelial growth factor (VEGF) on ultrafiltration failure (UFF) in rats with peritoneal dialysis (PD). Sprague-Dawley (SD) male rats were classified into normal, sham operation, and uremic model groups. Uremic rats were subcategorized into uremia, PD2, VEGF shRNA-2, vector-2, PD2 + Endostar, PD4, VEGF shRNA-4, Vector-4, a...

Metal ion adsorbents are indispensable materials for the recovery of noble metal ions in a sustainable society. Herein, we report that poly(isopyrazole-3,5-diyl-trans-vinylene) (1) effectively adsorbed group 10 from solution acetonitrile. Owing to its fully π-conjugated and rigid structure, polyimine 1 was virtually insoluble common organic solvents water, making it advantageous adsorption via ...

A hybrid proportional double derivative and linear quadratic regulator (PD2-LQR) controller is designed for altitude (z) attitude (roll, pitch, yaw) control of a quadrotor vehicle. The derivation mathematical model the formulated based on Newton–Euler approach. An appropriate controller’s parameter must be obtained to obtain superior performance. Therefore, we exploit advantages nature-inspired...

The capacity of self-organized systems to adapt is embodied in the functional organization of intrinsic control mechanisms. Evolution in functional complexity of heart rate variability (HRV) was used as measure of the capacity of the transplanted heart to express newly emergent regulatory order. In a cross-sectional study of 100 patients after (0-10 yr) heart transplantation (HTX), heart rate d...

One of the biggest challenges of premature birth is acute hypoxia. Hypothermia during acute hypoxic periods may be beneficial. We hypothesized that prevention of hypothermia during neonatal hypoxia disrupts glucose homeostasis and places additional metabolic challenges on the neonate. Pups at PD2 and PD8 were exposed to 8% O2 for 3 h, during which they were allowed to either spontaneously cool ...