The onset characteristics of pancuronium, tubocurarine and a mixture of these two neuromuscular blocking drugs were studied during the induction of neuromuscular blockade, using a train-of-four pattern of stimulation. Four characteristics of onset were defined: train-of-four fade = a reduction in the height of the fourth twitch greater than a reduction in the height of the first twitch; latent ...

Calf muscle blood flow was measured in eight patients with confirmed ischaemic disease of their lower limbs, before and during general anaesthesia which included pancuronium bromide and intermittent positive pressure ventilation. Anaesthesia was associated with a decrease in limb blood flow. Comparison of these results with those of a similar study in which tubocurarine was employed in a place ...

The haemodynamic effects of large bolus doses of metocurine 0.45 mg kg-1 and pancuronium 0.1 mg kg-1 were compared in patients with coronary artery disease anaesthetized with diazepam, anileridine and nitrous oxide. Hypotension occurred more frequently after metocurine and was a result of a decrease in systemic vascular resistance. After pancuronium there was no increase in arterial pressure or...

In vitro studies using the rat phrenic nerve-hemidiaphragm preparation were performed to investigate the effects of diazepam and three of its metabolites on indirectly evoked twitch tension. Diazepam, desmethyldiazepam and temazepam alone caused an increase in twitch tension in lower concentrations, followed by complete depression in higher concentrations. Oxazepam did not cause an initial incr...

experimental investigation performed in dogs in vivo has found no beneficial effect with paneuronium on pulmonary resistance, 6 contrary to what was expected by Kuwahara and Goresky from pancuronium sympathomimetic properties. Moreover, low doses of pancuronium increased pulmonary resistance (likely by blocking prejunctional M2-muscarinic receptors) whereas vecuronium was devoid of this side ef...

The effect of pancuronium bromide (0.025 mg/kg. B.W.) alone or combined with diazepam (1mg/Kg. I.V) were evaluated in six adult ewes. Pancuronium bromide alone exhibited a muscle relaxants effect, but without analgesia. All baseline measurements were taken before the administration the anesthetic agent and were repeated at 5,10,15,20 and 25 min. intervals after induction an aesthesia alone or c...

conclusions this study highlights potentiation effect of a defasciculating dose of pancuronium on succinylcholine paralysis suggesting the lack of justification to increase succinylcholine dosage. results the duration of succinylcholine induced paralysis (1 and 1.5 mg/kg) was significantly prolonged with pre-treatment with pancuronium but succinylcholine 1mg/kg did not reached maximum blockade ...

The pharmacokinetics of pipecuronium 0.07 mg kg-1 and pancuronium 0.1 mg kg-1 were compared in 39 ASA class I or II patients. Plasma concentrations of these agents were measured for 6 h following administration, using a sensitive and specific capillary gas chromatographic assay. Concentration v. time data were analysed by non-linear regression and fitted to a two- or three-compartment model as ...

We have determined the relative potency of rocuronium, pancuronium, pipecuronium and vecuronium, and examined the nature of the interaction of rocuronium with the other three steroidal neuromuscular blocking drugs. We studied the dose-response relationships of each drug and their combination with rocuronium in 200 ASA I or II patients during propofol-fentanyl-nitrous oxide-oxygen anaesthesia. N...

The influence of the primary bile salts taurocholate and chenodeoxycholate on the neuromuscular blockade of the non-depolarizing drugs Org 6368, pancuronium, Org NC 45 and hexafluorenium was studied in cats. An increase in the effects of these agents, all possessing widely varying molecular structures, was found following administration of the bile salts. The bile salt concentrations in plasma ...