Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

cyclooxygenase-2 (cox-2) has a pivotal role in the pathogenesis of the lung cancer. it is known that cox-2 negatively regulates the activity of a number of tumor suppressors, including p53. consequently, inhibition of cox-2 signaling is anticipated to be a promising approach to stabilize p53 functionality. in this regard, we investigated the effect of cox-2 signaling blockade on p53 and cox-2 e...

the p53 protein is expressed in all normal cells and appears to function in cell cycle regulation. abnormally higli levels of the protein are found in many different types of cancer. in breast cancer, overexpression of p53 is associated with point mutations within highly conserved regions of the p53 gene. these altered genes encode stable p53 protein that can be detected by standard immunohisto...

Background: A major worry of juvenile penile LS is potential malignant degeneration to spinocellular carcinoma (SCC) in adulthood. characterized by increased CD8+ and CD57+ cells, dermal sclerosis, epidermal atrophy, hyperkeratosis. p53 Ki67 are reliable premalignant markers. Our aim was define the immunohistochemical profile foreskin children, focusing on tissue immune response cell proliferat...

Background: Prostate cancer is one of the most commonly diagnosed cancers in males. Tumor suppressor gene p53 plays an important role in causing cell cycle arrest and allowing apoptosis to proceed. Objective: To investigate the expression of p53 protein and its relation to apoptosis and prostate cancer traditional prognostic indicators. Methods: In this study expression of p53 was examined in p...

the gene tp53 (also known as protein 53 or tumor protein 53), encoding transcription factor p53, is mutated or deleted in half of human cancers, demonstrating the crucial role of p53 in tumor suppression. there are reports of nearly 250 independent germ line tp53 mutations in over 100 publications. the p53 protein has the structure of a transcription factor and, is made up of several domains. t...

background: the most frequently mutated tumor suppressor gene found in human cancer is p53. in a normal situation, p53 is activated upon the induction of dna damage to either arrest the cell cycle or to induce apoptosis. however, when mutated, p53 is no longer able to properly accomplish these functions. the aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...

Mutational inactivation of p53 is a key player in the development of human cancer. Thus, retrieving the tumor suppressor activity of p53 gene is considered a novel strategy in cancer therapy. Current study aimed to investigate the anti-cancer potentials of botulinum toxin type-A (BTX-A) and captopril as a trial to shed light on effective anti-cancer therapy with lower side effects. Cytotoxic ef...