Distinct immune responses in humans to the Trichophyton rubrum Ag, Tri r 2, are associated with different patterns of T cell epitope recognition based on in vitro proliferation to peptides derived from this 29-kDa protein. Specifically, the amino-terminal immunodominant epitope, peptide 5 (P5), stimulates strong T cell proliferative responses in subjects with delayed (DTH), but not immediate (I...

Three separate studies, two involving active-immunization regimens and one involving a passive-transfer protocol, were conducted to initially screen and ultimately more fully assess several nontypeable Haemophilus influenzae outer membrane proteins or their derivatives for their relative protective efficacy in chinchilla models of otitis media. Initial screening of these antigens (P5-fimbrin, l...

A dynamic program slice is the part of a program that affects the computation of a variable of interest during program execution on a specific program input. Dynamic slices are usually smaller than static slices and are more useful in interactive applications such as program debugging and testing. The understanding and debugging of multithreaded and distributed programs are much harder compared...

Reaction of [U(TrenTIPS)] [1, TrenTIPS=N(CH2CH2NSiiPr3)3] with 0.25 equivalents of P4 reproducibly affords the unprecedented actinide inverted sandwich cyclo-P5 complex [{U(TrenTIPS)}2(μ-η5:η5-cyclo-P5)] (2). All prior examples of cyclo-P5 are stabilized by d-block metals, so 2 shows that cyclo-P5 does not require d-block ions to be prepared. Although cyclo-P5 is isolobal to cyclopentadienyl, w...

The main protease (Mpro) of severe acute respiratory syndrome coronavirus (SARS CoV) is a key enzyme for viral replication, and is thus an attractive target for anti-SARS CoV drug development. Mpro belongs to the family of 3C-like cysteine proteases. The basic design of peptidomimetic inhibitors involved a warhead that can form covalent modifications to the –SH group of the active site residue ...