نتایج جستجو برای: p2x3

تعداد نتایج: 460  

2014
Lizhao Wang Dan Feng Huanhuan Yan Zhongping Wang Lei Pei

Nodose ganglion (NG) neurons are visceral primary sensory neurons. The transmission and regulation of visceral sensation is mediated mainly by the P2X purinoceptor (P2X receptor). Although the characteristics of different P2X receptor subunits in the NG have been studied previously, comprehensive analyses have not been performed. In this study, we used immunohistochemistry, immunocytochemistry,...

2014
Yi Ye Kentaro Ono Daniel G Bernabé Chi T Viet Victoria Pickering John C Dolan Markus Hardt Anthony P Ford Brian L Schmidt

INTRODUCTION Cancer pain creates a poor quality of life and decreases survival. The basic neurobiology of cancer pain is poorly understood. Adenosine triphosphate (ATP) and the ATP ionotropic receptor subunits, P2X2 and P2X3, mediate cancer pain in animal models; however, it is unknown whether this mechanism operates in human, and if so, what the relative contribution of P2X2- and P2X3-containi...

Journal: :Mechanisms of Development 2000
William H.J Norton Klaus B Rohr Geoffrey Burnstock

From studies performed primarily in mammals, it is thought that the P2X(3) purinoreceptor is involved in mediating sensory and nociceptive signals in adult tissues. However, little is known concerning the expression or function of P2X family genes during early development. Here we describe the expression of a gene (p2x3) encoding a P2X(3) receptor during zebrafish development. We find that zebr...

Journal: :Journal of applied physiology 2010
Jennifer L McCord Hirotsugu Tsuchimochi Marc P Kaufman

The exercise pressor reflex is due to activation of thin fiber afferents within contracting muscle. These afferents are in part stimulated by ATP activation of purinergic 2X (P2X) receptors during contraction. Which of the P2X receptors contribute to the reflex is unknown; however, P2X2/3 and P2X3 receptor subtypes are good candidates because they are located on thin fiber afferents and are inv...

Journal: :The Journal of biological chemistry 2012
Ralf Hausmann Mandy Bodnar Ronja Woltersdorf Haihong Wang Martin Fuchs Nanette Messemer Ying Qin Janka Günther Thomas Riedel Marcus Grohmann Karen Nieber Günther Schmalzing Patrizia Rubini Peter Illes

The aim of the present experiments was to clarify the subunit stoichiometry of P2X2/3 and P2X2/6 receptors, where the same subunit (P2X2) forms a receptor with two different partners (P2X3 or P2X6). For this purpose, four non-functional Ala mutants of the P2X2, P2X3, and P2X6 subunits were generated by replacing single, homologous amino acids particularly important for agonist binding. Co-expre...

Journal: :Molecular pharmacology 2006
Elena Sokolova Andrei Skorinkin Igor Moiseev Andrei Agrachev Andrea Nistri Rashid Giniatullin

The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. Two types of desensitization were observed, a fast process (t1/2 = 50 ms; 10 microM ATP) fo...

2014
Igor Sterle Daša Zupančič Rok Romih

Terminal differentiation of urothelium is a prerequisite for blood-urine barrier formation and enables normal sensory function of the urinary bladder. In this study, urothelial differentiation of normal human urothelium and of low and high grade papillary urothelial carcinomas was correlated with the expression and localization of purinergic receptors (P2X3, and P2X5) and transient receptor pot...

Journal: :Nucleic acids research 2004
Gabriele Dorn Sadhana Patel Glen Wotherspoon Maja Hemmings-Mieszczak Jane Barclay Francois J C Natt Pierre Martin Stuart Bevan Alyson Fox Pam Ganju William Wishart Jonathan Hall

Double stranded, short interfering RNAs (siRNA) of 21-22 nt length initiate a sequence-specific, post-trancriptional gene silencing in animals and plants known as RNA interference (RNAi). Here we show that RNAi can block a pathophysiological pain response and provide relief from neuropathic pain in a rat disease model by down regulating an endogenous, neuronally expressed gene. Rats, intratheca...

Journal: :Journal of Immunology 2023

Abstract The rising incidence of allergic disease is a public health challenge needing novel interventions. Mast cell activation by IgE an established feature allergy, but fundamental aspects IgE-induced signaling remain unclear. Prior data from our lab testing the effects fluoxetine on IgE-driven mast function indicated role for purinergic receptor P2X3. P2X3 ATP-activated cationic channel mos...

Journal: :Drug development research 2001
Sean G Brown Yong-Chul Kim Soon-Ai Kim Kenneth A Jacobson Geoffrey Burnstock Brian F King

[Table: see text] Seven PPADS (Pyridoxal-5'-Phosphate 6-Azophenyl 2',4'-DiSulfonate) analogs were investigated at Group 1 P2X receptors expressed in Xenopus oocytes. All seven analogs potently inhibited P2X1 (IC50 range, 5-32 nM) and P2X3 (IC50 range, 22-345 nM), the two Group I P2X receptor subtypes. Analogs showed greater inhibitory activity where the pyridoxal moiety of PPADS contained a 5'-...

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