4 5 6 7 Chongxu Zhang, Crystal Adamos, Myung-Jin Oh, Jugajyoti Baruah, Manuela A.A. Ayee, 8 Dolly Mehta, Kishore K. Wary, Irena Levitan 9 10 Division of Pulmonary and Critical Care, Department of Medicine and Department of 11 Pharmacology, University of Illinois at Chicago 12 13 14 Running Title: OxLDL and endothelial proliferation 15 16 17 18 19 20 21 Corresponding Author: 22 Irena Levitan 23 ...

Interaction of oxidized LDL (OxLDL) with macrophage-derived foam cells is one of the key events in the development and progression of atherosclerosis. To study this interaction, macrophage-derived foam cells were isolated from rabbit atherosclerotic lesions and the expression of scavenger receptors for OxLDL was examined. Atherosclerosis was induced in rabbits by denudation of the large arterie...

Fig 4 is incorrect. The correct Fig 4 is available here. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

BACKGROUND Several studies suggest that C-reactive protein (CRP) is associated with coronary artery disease in adults. However, this association has not been thoroughly explored in cases of adolescents. OBJECTIVE To evaluate the association between CRP and cardiovascular risk factors in obese adolescents. METHODS Eighty-four adolescents (12.6 +/- 1.3 years) of both genders were divided into...

This image-object relationship has been evaluated in a radiographic study of ox femora. The soft tissues were removed from the proximal ends of 5 specimens and the bones were each cut in the medio-lateral plane into 5 slices. The image of the trabecular pattern on the radiograph of each slice was very different to that of the whole bone. These trabecular patterns are diagramatically represented...

We have previously shown that CD36 recognizes oxidation products of phospholipids on oxidized LDL (OxLDL) such as 1-palmitoyl-2-(5'-oxovaleroyl)-sn-glycero-3-phosphocholine (POVPC). The current study was designed to examine whether the phosphocholine (PC) headgroup in POVPC constitutes an obligatory binding target for CD36. To examine the contribution of PC in the binding of POVPC to CD36, we u...

Cyclosporine and in particular oxidatively modified low density lipoproteins can both exert direct vasoconstricting effects. We hypothesized that coincubation of arteries with low density lipoproteins and cyclosporine would enhance their respective influence on vascular tone. Therefore, we investigated vascular reactivity of isolated intact rabbit renal arteries preincubated with cyclosporine i...

Background: Atherosclerosis, a chronic inflammatory disease of the vessel wall is characterized by local and systemic immune responses to a variety of antigens. Oxidized low-density lipoprotein (oxLDL) is considered as an important determining factor in the pathogenesis of atherosclerosis. Objective: The purpose of this study was to investigate the degree of peripheral blood mononuclear cells (...

Binding of beta(2)-glycoprotein I (beta(2)-GPI)-dependent anticardiolipin antibodies (aCL) derived from antiphospholipid syndrome (APS) is significantly reduced in aCL ELISA due to loss of the phospholipid (PL) binding property of beta(2)-GPI by plasmin treatment. In the present study, the treatment generated a nicked form of beta(2)-GPI and resulted in loss of antigenicity for the autoantibodi...

In 1981, Henriksen and coworkers 1 reported that oxidized LDL (oxLDL) induces cholesterol accumulation in macrophages. This observation formed the basis of the hypothesis that oxidation of LDL might be an important step in the atherogenesis process. Many subsequent studies support the oxidative modification hypothesis of atherogenesis.2–4 However, oxidation of LDL is a complex process. Both the...