The installation of dental implants has become a common treatment for edentulous patients. However, concern exists about the influence osteoporosis on final implant success. This study evaluated whether an ovariectomy (OVX)-induced osteoporotic condition, induced eight weeks postimplantation in rat femoral condyle, influences bone response to already-integrated implants. were inserted condyle 1...

Hormone responsiveness of autonomous and diversely hormone-responsive mammary tumors of the rat was assayed in organ cultures by measuring DNA synthesis. Rat sera rich in hormones secreted by mammotropic pituitary cells were compared with sera of normal female and male and of ovariectomized and hypophysectomized rats. Mammotropic sera invariably stimulated DNA synthesis of hormoneresponsive tum...

The pharmacological preservation of bone in the ovariectomized rat by estrogen, selective estrogen receptor modulators (SERMs), and bisphosphonates has been well described. However, comprehensive molecular analysis of the effects of these pharmacologically diverse antiresorptive agents on gene expression in bone has not been performed. This study used DNA microarrays to analyze RNA from the pro...

Objectives: Ovariectomy of young rodents is the most frequently used animal model of the menopause. However, the assumption that ovariectomy, causing a rapid loss of ovarian hormones is a general model of menopause in not well supported. Several animal models have been developed with the aim of mitigating the human conditions of the menopause. Among these, the ovotoxin 4-vinylcyclohexene diepox...

Prior to initiating a clinical trial in a post-menopausal osteoporosis study, it is reasonable to recommence the evaluation of treatment in the 9-month-old ovariectomized female rat. A female rat of this age has reached peak bone mass and can be manipulated to simulate clinical findings of post-menopausal osteoporosis. Ample time exists for experimental protocols that either prevent estrogen de...

Licorice is a medicinal plant showing many therapeutic activities. Its roots contain numerous pharmacologically active compounds such as a triterpenoid saponin--glycyrrhizic acid and an isoflavan--glabridin. There are reports indicating that glabridin exhibits estrogen-like activity, therefore it can be classified into phytoestrogens, which may soothe menopause symptoms including postmenopausal...

There is evidence that estrogen can upregulate nitric oxide (NO) synthase expression. There is also evidence that NO increases the activity of prostaglandin H synthase (PGHS). Our initial hypothesis was that removal of ovarian steroids would decrease endothelium/NO-dependent relaxation responses but that estrogen replacement would increase NO and PGHS activity, leading to increased vasodilation...

Thawornkaiwong A, Pantharanontaga J, Wattanapermpool J. Hypersensitivity of myofilament response to Ca in association with maladaptation of estrogen-deficient heart under diabetes complication. Am J Physiol Regul Integr Comp Physiol 292: R844–R851, 2007. First published October 12, 2006; doi:10.1152/ajpregu.00365.2006.— The amelioration of cardioprotective effect of estrogen in diabetes suggest...

Adlay (Coix lachryma-jobi L. var. ma-yuen Stapf ) is a grass crop, which has been used in traditional Chinese medicine and also as a nourishing food. Recently, some studies have indicated that adlay possesses some pharmacological effects including anti-allergic, anti-mutagenic, hypolipemic, and anti-diabetic effects. However, the effect of adlay on osteoporosis is still unknown. In this study, ...

We tested the hypothesis that endothelium-derived hyperpolarizing factor (EDHF) plays a less dominant role in the female cerebrovasculature. The contribution of EDHF to the ATP-mediated dilation was determined in middle cerebral arteries (MCAs) isolated from male and female rats. Four groups of rats were tested: intact male (n = 12), intact female (n = 13), estrogen-treated ovariectomized femal...