Proteins are the biomolecular workhorses driving the most biological processes in any living organism. These processes are based on selective interactions between particular proteins. So far, the rules governing the coding of the protein’s biological function, i.e. its ability to selectively interact with other biomolecules, have not been elucidated. The resonant recognition model (RRM) is a no...

Abstract Background In order to facilitate the safe and long-term delivery of peritoneal dialysis (PD), it is necessary improve biocompatibility fluids (PDFs). The novel bicarbonate/lactate-buffered neutral PDFs (B/L-PDFs) are expected be improved biocompatible. This study evaluated B/L-PDFs by analysis on profile angiogenesis-related proteins in drained dialysate patients undergoing PD. Method...

Purpose Radiation therapy is a viable treatment option for patients with unresectable hepatocellular carcinoma (HCC). However, radiation resistance and adverse effects are issues that needs to be addressed. Herein, the first time, we investigated ability of collectrin (CLTRN) enhance radiosensitivity in HCC. Methods Materials Transcriptome sequencing technology (RNA-seq technology) was used ana...

There is a growing body of evidence supporting the significant role bacterial biofilms in pathogenesis various human diseases, including cancer. Biofilms are polymicrobial communities enclosed within an extracellular matrix composed polysaccharides, proteins, DNA, and lipids. This complex provides protection against antibiotics host immune responses, enabling microorganisms to establish persist...

medullary thyroid carcinoma (mtc) occurs in both sporadic (75%) and hereditary (25%) forms. the missense mutations of the rearranged during transfection (ret) proto-oncogene in mtc development have been well demonstrated. the aim of this study was to investigate frequency of g691s/s904s haplotype in mtc patients and their relatives.in this research 293 participants were studied, including 181 p...

abstract :  reovirus (respiratory enteric orphan virus), a naturally occurring benign human pathogen, has an inherent ability to target transformed and cancerous cells and cause their lysis, while leaving non-transformed cells relatively unaffected.  the efficiency of this innate oncolytic activity of reovirus correlates with expression of the ras oncogene.  cells expressing activated ras and t...