BACKGROUND Oleuropein is a phenolic compound which is present in the olive leaf extract. The purpose of the present study was to investigate the neuroprotective effect of oleuropein as an antioxidant agent on the substantia nigra in aged rats. METHODS Twenty 18-month-old Wistar rats (450-550 g) were randomly divided into control and experimental groups. The experimental group received a daily...

AIMS Oleuropein and hydroxytyrosol, which are antioxidant molecules found in olive leaves and oil, have been reported to exert several biochemical and pharmacological effects. These polyphenols are able to prevent low-density lipoprotein oxidation and protect cells against several diseases. Here, we studied the effect of these compounds on adipocyte differentiation in 3 T3-L1. MAIN METHODS To...

The chemical composition of finished table olive products is influenced by the olive variety and the processing method used to debitter or cure table olives. Herein, a rapid ultrahigh-pressure liquid chromatography triple-quadrupole tandem mass spectrometry method, using dynamic multiple reaction monitoring, was developed for the quantitation of 12 predominant phenolic and secoiridoid compounds...

Response surface methodology (RSM) and artificial neural networks (ANN) were evaluated and compared in order to decide which method was the most appropriate to predict and optimize total phenolic content (TPC) and oleuropein yields in olive tree leaf (Oleaeuropaea) extracts, obtained after solvent-free microwave-assisted extraction (SFMAE). The SFMAE processing conditions were: microwave irradi...

olives and olive oil contain large amounts of oleuropein. this phenolic compound is responsible for theirbitter taste and pungent aroma and has been recognized as a powerful hypotensive, hypoglycemic andantioxidant agent. thus, the aim of the present study was to evaluate the antioxidant properties of oleuropein on ethanol-induced oxidative damage and to examine its beneficial effects on liver ...

This study was designed to test the antidiabetic and antioxidative activities of olive leaf oleuropein and hydroxytyrosol. Diabetes in Wistar rats was induced by intraperitoneal injections of alloxan. The serum glucose and cholesterol, hepatic glycogen, the thiobarbituric acid-reactive substances (TBARS), and the components of hepatic and serum antioxidant system were examined. Diabetic rats sh...

Olive from Olea europaea is native to the Mediterranean region and, both the oil and the fruit are some of the main components of the Mediterranean diet. The main active constituents of olive oil include oleic acid, phenolic constituents, and squalene. The main phenolic compounds, hydroxytyrosol and oleuropein, give extra-virgin olive oil its bitter, pungent taste. The present review focuses on...

Olive leaf extracts possess broad biological activity including antimicrobial properties.Studies have provided evidence suggesting that the extracts increase activity againstdifferent pathogens. 4 Although the extract mixture show antimicrobial activity, theactive compound has not been identified. East Park Research (EPR) developed anextraction process of olive leaves that d...