background and objective: an outer membrane protein (omp) of helicobacter pylori namely oipa, is an important vir- ulence factor associated with peptic ulcer and gastric cancer risks. the purpose of this study was to isolate the 34 kda omp of h. pylori and evaluate its immunogenicity in experimental animals for rapid detection of more virulent h. pylori isolates. material and methods: sarcosine...

Associations of Helicobacter pylori genotypes with disease differ between Western countries and Asia. Therefore, we directly compared histopathological and in vitro responses to clinical isolates with similar genotypes. Sixty-three cagA(+) vacAs1/m1 H. pylori isolates (United States, n = 24; Japan, n = 39) and eight cagA-negative vacAs2/m2 strains were incubated with AGS cells, and supernatants...

Background: Helicobacter pylori (H. pylori or Hp) has been strongly associated with the peptic ulcer diseases, chronic gastritis, ulcers, and gastric cancer. Genes associated with pathogenicity have been designated for H. pylori, and some of them appear to be related to more severe clinical consequences of the infection. The present study was conducted to determine cagA, vacA, cagE, iceA1, oipA...