Human cytotoxic T cells specific for influenza A virus were tested for recognition of each of the ten influenza A virus proteins expressed in target cells using recombinant vaccinia viruses. They recognized the matrix M1, polymerase PB2, and nucleoproteins of influenza virus in association with MHC class I antigens. These internal viral proteins were seen by CTL in conjunction with one or more ...

THE ROLE OF THYMONUCLEIC ACID IN NORMAL CELLS Chromosomes and Genes Cytoplasmic Nucleic Acids Protein Synthesis Bacteria and Filterable Viruses THE ROLE OF THYMONUCLEIC ACID IN NEOPLASTIC CELLS The Significance of Nucleic Acids in the Somatic Mutation Theory of Etiology Chemical Evidence of Disturbance of Nucleic Acids in Tumors Histochemical and Cytochemical Evidence of Disturbance of Thymonuc...

Background and Aims: Influenza virus nucleoprotein (NP) has the capacity to be used as subunit vaccine, but little is known about the impact of different cultures on its structure. In the present study we aimed to evaluate and compare the Isoelectric focusing (IEF) property of extracted viral nucleoproteins derived from Madin Darby canine kidney (MDCK) cell line and embryonated chicken eggs (EC...

supposed that genes control ultimately all cellular functions, including protein synthesis. From the close association of genes with nucleoproteins, it is natural to assume that nucleic acids may be in volved in protein synthesis. Such an assumption can be supported by the fact that nucleic acids are always found associated with self-duplicating units (e.g., genes, viruses, plastids, transformi...

Hemorrhagic fever with renal syndrome (HFRS) is an acute viral zoonosis carried and transmitted by infected rodents through urine, droppings, or saliva. The etiology of HFRS complex due to the involvement factors host immune genetic which hinder development potential therapeutic solutions for HFRS. Hantaan virus (HTNV), Dobrava-Belgrade (DOBV), Seoul (SEOV), Puumala (PUUV) are predominantly fou...

We have documented that the nucleoprotein (NP) of the prototypic arenavirus lymphocytic choriomeningitis virus is an antagonist of the type I interferon response. In this study we tested the ability of NPs encoded by representative arenavirus species from both Old World and New World antigenic groups to inhibit production of interferon. We found that, with the exception of Tacaribe virus (TCRV)...

It can be postulated that the striking biological specificity shown by viruses is determined by or associated with certain specific nucleoproteins contained in the viral particle. If this be true, then it might be possible to inhibit viral multiplication without interfering with the function of host cell nucleoproteins, provided that sufficiently selective means were available. Such means are n...